基于WOS数据库近十年肠道菌群与肿瘤相关性研究热点的可视化分析

Visual Analysis of Research Hot Spots on Reciprocity between Intestinal Microbial Population and Tumor in Recent Past Decade Based on WOS Database

对近十年肠道菌群与肿瘤相关性的研究热点和发展趋势进行可视化分析。从WOS数据库搜索并筛选2012年至2022年的文献,运用VOSviewer 1.6.18对国家、机构、作者、期刊以及关键词进行共现分析,Citespace 6.1.R6对关键词进行聚类和时间线图分析发现,发文量呈逐年上升趋势,而中国在发文量、机构和核心作者方面具有一定优势,美国在中心性、发文期刊和合作方面具有一定优势。期刊和文献共被引分析得出Science在该研究方面贡献较大。关键词共现说明目前以gut microbiota为中心,分别从inflammation、expression和probiotics方向进行研究。关键词聚类由810个节点和3681条线组成,形成12个聚类,主要分为四类:A类为各类肿瘤与肠道菌群的研究;B类为以益生元为代表的研究;C类为通过信号通路、免疫、炎症、氧化应激等相关机制的研究;D类为利用宏基因技术分析与肿瘤相关的特异菌群。本文基于文献计量分析了肠道菌群与肿瘤相关性当前研究热点和发展趋势,有利于研究者明确该方向的热点,为今后研究提供参考。

Research hot spots and development trend of the reciprocity between intestinal microbial population and tumors in recent past decade were visually analyze.The documents from 2012 to 2022 were searched and screened from the WOS database,co-occurrence analysis of countries,institutions,authors,periodicals and keywords was carried out using VOSviewer 1.6.18,Citespace 6.1.R6 was used for clustering and timeline analysis of keywords.The number of papers issued increased year by year.China has a certain advantage in the volume of publications,institutions and core authors,while the United States has a certain advantage in centrality,publications and cooperation.The co-cited analysis of journals and articles showed that Science has made a great contribution to the researches.Keywords co-occurrence indicated that at present,the researches are centered on intestinal microbial population,and is conducted from the aspects of inflammation,expression,and probiotics respectively.Keywords cluster is composed of 810 nodes and 3681 lines,forming 12 clusters,which are mainly divided into four categories:A is the study of various tumor and intestinal flora;B is the research represented by probiotics;C is the study of related mechanisms such as signal pathway,immunity,inflammation and oxidative emergency-response;D is the use of macro gene technology to analyze the specific bacterial populations associated with tumor.Based on the bibliometrics analysis of the current research highlights and development trends of the reciprocity between intestinal bacterial population and tumors,this paper is conducive to the researchers to identify the hot spots in this direction and provide reference ideas for future researches.