炎症性肠病患者粪便标本采集管理的最佳证据总结

Optimal evidence-based summary for management of faecal specimen collection in patients with inflammatory bowel disease

目的 检索、评价和整合炎症性肠病(inflammatory bowel disease,IBD)患者粪便标本采集管理的最佳证据,为制定临床标本采集管理提供循证依据。方法 参照“6S”证据金字塔模型,计算机检索UpToDate,JBI循证卫生保健数据库,BMJ最佳临床实践(BMJ Best Practices),美国国立指南网(National Guideline Clearinghouse,NGC),加拿大安大略注册护士协会(Registered Nurses’ Association of Ontario,RNAO),苏格兰校际指南网(Scottish Intercollegiate Guidelines Network,SIGN),美国微生物学会(American Society for Microbiology,ASM),Cochrane Library,PubMed,Web of Science,Embase,中国知网,万方,中国生物医学文献数据库与IBD相关协会,丁香园、医脉通中关于IBD患者粪便标本采集管理的临床决策支持系统、指南、专家共识、系统评价、证据总结、原始研究,检索时间为建库至2023年6月10日。由2名研究者对文献质量进行评价,并对符合质量标准的文献进行证据提取。结果 共纳入9篇文献,其中计算机临床决策1篇,指南3篇,专家共识3篇,系统综述1篇,证据总结1篇,对证据进行汇总后,总结出最佳证据27条,包括采集前准备、采集时机、采集方法、保存和转运、健康教育5方面。结论 本研究总结了IBD患者粪便标本采集管理的最佳证据,为护理人员提供了循证依据,医护人员可根据临床实际情况应用证据,以便提高该疾病监测与诊断的准确性。

Objective To select,evaluate and integrate the optimal evidence for collection of faecal specimen and management of patients with inflammatory bowel disease(IBD),therefore to provide evidence-based strategies for specimen collection.Methods According to the model of"6S"evidence,systematic search was performed on UpToDate,JBI evidence-based healthcare database,BMJ Best Practice,National Guideline Clearinghouse(NGC),Registered Nurses’Association of Ontario(RNAO),Scottish Intercollegiate Guidelines Network,(SIGN),American Society for Microbiology(ASM),Web of Science,Cochrane Library,PubMed,Embase,CNKI,Wanfang Data,Chinese Biomedical Literature Database and the associations related to IBD,DXY,Medlive in order to acquire information in relation to the collection of faecal specimens and management of patients with IBD.Data were searched from the inception of databases to June10th 2023.Quality evaluation and evidence extraction of the literatures were performed by two researchers to ensure that the literatures were met with the quality standards.Results A total of nine articles were included and they were 1 clinical decision,3 clinical guidelines,3 expert consensus,1 systematic review and 1 evidence summary.Finally,27 pieces of evidence were summarised from five aspects including preparation before sampling,sampling time,sampling method,preservation and transportation,and health education.Conclusions This study summarises the best evidences in faecal collection from IBD patients,which can provide evidence-based strategies for standardised collection of clinical faecal specimens.Medical staff can apply the evidences according to clinical conditions hence to improve the accuracy in monitoring and diagnosis of IBD.