初潮年龄与多囊卵巢综合征发病风险相关性的系统评价与meta分析

Relationship between age at menarche and polycystic ovarian syndrome: a systematic review and meta-analysis

目的系统评价初潮年龄与多囊卵巢综合征(polycystic ovary syndrome,PCOS)的关系。方法计算机检索11个数据库,搜集有关初潮年龄和PCOS的研究,检索时限为建库以来到2023年9月1日。由两位评价员独立按纳入标准筛选文献、提取资料后进行meta分析。所有统计分析均使用Stata17.0软件进行。结果从检索的3107篇文献中筛选得到10篇符合标准的文献,包含6462个研究对象。meta分析结果显示,初潮年龄延迟PCOS发病风险是初潮年龄正常PCOS发病风险的1.84倍(95%CI:1.14~2.97),初潮年龄提前与初潮年龄正常相比,PCOS发病风险未见统计学意义(P>0.05)。结论初潮年龄延迟是PCOS发生的危险因素。

Objective:To systematically evaluate the connection between polycystic ovary syndrome(PCOS)and age at menarche.Methods:We searched 11 databases from inception to September 1st 2023 to collect studies about the association between age at menarche and PCOS.Two reviewers independently screened literatures,accordance with the inclusion criteria and extracting the data,extracted data and performed meta-analysis by Stata17.0 software.Results:A total of 10 literatures,including 6462 subjects,were included at last in the study.A meta-analysis revealed that there was no statistically significant difference in the risk of getting PCOS between early and normal age at menarche,and the risk of PCOS with delayed age at menarche was 1.84(95%CI:1.14-2.97)times greater than that with normal age at menarche.Conclusion:There may be a connection between delayed age at menarche and the development of PCOS.