帕金森病与肌张力障碍之间相关性的研究进展

Research progress on the association between Parkinson's disease and dystonia

肌张力障碍是一种由于过度运动导致的运动障碍综合征,由于不同状态的肌肉收缩,产生重复运动或异常姿势,或两者兼而有之,在多种遗传性、代谢性、退行性疾病中可能存在,其中在帕金森病中最为常见。作为一种中老年常见的神经系统变性疾病,帕金森病具有大量运动和非运动特征,可对功能产生不同程度的影响,其发病机制以及治疗方法仍在深入探索当中。帕金森病相关肌张力障碍类型繁多,现总结帕金森病相关肌张力障碍的发病机制和不同发病部位,并简要概述其治疗,以期为临床医师对帕金森病相关肌张力障碍提供新的参考。

Dystonia is a movement disorder syndrome caused by excessive exercise,which can result in repetitive movements or abnormal postures due to muscle contractions in different states,or both.It may exist in various genetic,metabolic,and degenerative diseases,among which Parkinson's disease is the most common.As a common neurodegenerative disease in the middle-aged and elderly,Parkinson's disease has a large number of motor and non motor characteristics,which can have varying degrees of impact on function.Its pathogenesis and treatment methods are still being explored in depth.There are many types of Parkinson's disease related muscle tone disorders.This article summarizes the pathogenesis and different sites of Parkinson's disease related muscle tone disorders,and briefly outlines their treatment,in order to provide new references for clinical doctors to treat Parkinson's disease related dystonia.