地骨皮乙酸乙酯部位化学成分研究

Chemical Constituents from Ethyl Acetate Parts of Lycii Cortex

目的 研究地骨皮的化学成分。方法 采用传统分离手段对地骨皮75%乙醇提取物进行化学成分研究,并通过NMR、ESI-MS等技术鉴定单体化合物的结构。结果 从地骨皮75%乙醇提取物中得到16个化合物,分别鉴定为2-hydroxy-3、4-dimethoxybenzaldehyde (1)、β-谷甾醇 (2)、vanillin (3)、springaldehyde (4)、6,7-dimethoxycoumarin (5)、scopoletin (6)、去氢假虎刺酮 (7)、2-naphthalenemethanol,1,2,3,4-tetrahydro-4-hydroxy-α,α,5,8-tetramethyl (8)、2-甲氧基-5-烯丙基苯甲醛(9)、caruilignan D (10)、syringaresinol (11)、evofolin B (12)、(7S,8S,8'R)-3,3'-dimethoxy-7,9'-epoxylignane-4,4',9-triol (13)、canusesnol A (14)、7'-ethoxy-trans-feruloyltyramine (15)、corchoionol C (16)。结论 化合物1、9、10、15为首次从茄科植物中分离得到,化合物7、12、14为首次从枸杞属植物中分离得到,化合物4、11、13为首次从地骨皮中分离得到。

Objective To study the chemical constituents from ethyl acetate part of Lycii Cortex (the root bark of Lycium chinense).Methods The chemical constituents of 75% ethanol extract from Lycii Cortex were isolated by traditional separation methods,and their structures were elucidated by means of spectroscopic analysis(NMR and ESI-MS).Results 16 compounds were separated from Lycii Cortex and identified by spectroscopic analysis as:2-hydroxy-3,4-dimethoxybenzaldehyde(1),β-sitosterol(2),vanillin(3),springaldehyde(4),6,7-dimethoxycoumarin(5),scopoletin(6),dehydropseudophenone(7),naphthalenemethanol,1,2,3,4-tetrahydro-4-hydroxy-α,α,5,8-tetramethyl(8),2-methoxy-5-allylbenzaldehyde(9),caruilignan D(10),syringaresinol(11),evofolin B(12),(7S,8S,8'R)-3,3'-dimethoxy-7,9'-epoxylignane-4,4',9-triol(13),canusesnol A(14),7'-ethoxy-trans-feruloyltyramine(15),corchoionol C(16).Conclusion Compounds 1,9,10 and 15 are isolated from Solanaceae for the first time,compounds 7,12,14 are isolated from Lycium genus for the first time,and compounds 4,11,13 are isolated from Lycii Cortex for the first time.