长链非编码RNA在结直肠癌化疗耐药机制的研究进展

Advances in the study of long non-coding RNAs in chemoresistance mechanisms of colorectal cancer

长链非编码RNA(lncRNA)是一种内源性非编码RNA。化疗在结直肠癌(CRC)的治疗中担任重要的角色。多项研究表明,lncRNA通过不同机制导致CRC化疗耐药。因此,以lncRNA为靶点克服CRC化疗耐药的策略被提出。目前,已有研究证明一些化学药物和中药能靶向lncRNA逆转耐药性。该文主要综述了lncRNA在CRC化疗耐药机制的研究进展。

Long non-coding RNAs(lncRNAs)are endogenous non-coding RNAs that play significant roles in the chemoresistance mechanisms of colorectal cancer(CRC).Chemotherapy is a crucial treatment modality for CRC,but resistance to chemotherapy remains a major challenge.Various studies have demonstrated that lncRNAs contribute to CRC chemoresistance through dfferent mechanisms.Consequently,targeting lncRNAs to overcome CRC chemoresistance has been proposed as a therapeutic strategy.This review summarizes the recent advances in research on the mechanisms by which lncRNAs contribute to chemoresistance in CRC.