中药调控NF-κB信号通路改善多囊卵巢综合征的研究进展

Research progress on traditional Chinese medicine improving polycystic ovary syndrome by regulating NFκB signaling pathway

多囊卵巢综合征(PCOS)是育龄期妇女常见的生殖内分泌疾病。持续的慢性炎症可促进PCOS进展,从而对女性内分泌代谢、生殖功能及心理状态造成严重影响。核因子κB(NF-κB)信号通路是经典的炎症反应通路,与PCOS病理过程密切相关。本文基于NF-κB信号通路综述中药改善PCOS的作用机制,发现黄酮类(柚皮素、大豆异黄酮、鼠李柠檬素等)、生物碱类(黄连素、川芎嗪)、萜类(青蒿琥酯、隐丹参酮)、苷类(红景天苷、甘草酸)等中药单体及补肾类(补肾化瘀方、补肾化痰方等)、祛湿化痰类(苍附导痰汤、燮和饮、二陈汤)、理血化瘀类(膈下逐瘀汤、化痰通脉饮)等中药复方可通过抑制NF-κB信号通路,减轻炎症反应,改善糖脂代谢异常,增强卵巢功能,从而发挥改善PCOS的作用。

Polycystic ovary syndrome(PCOS)is a common endocrine disorder among women of childbearing age.Persistent chronic inflammation can promote the progression of PCOS,thereby causing serious impacts on women’s endocrine metabolism,reproductive function,and psychological status.Nuclear factors-κB(NF-κB)signaling pathway is one of the most classic inflammatory response transduction pathways and is closely related to the pathological process of PCOS.This article summarizes the mechanism of traditional Chinese medicine intervention in PCOS based on the NF-κB signaling pathway,and finds that various monomers of traditional Chinese medicine[flavonoids(naringenin,soy isoflavone,rhamnocitrin,etc.),alkaloids(berberine,ligustrazine)and terpenoids(artesunate,cryptotanshinone),glycosides(salidroside,glycyrrhizic acid)]and traditional Chinese medicine compounds[formula for tonifying kidney(Bushen huayu formula,Bushen huatan formula,etc.),formula for eliminating damp and dissolving phlegm(Cangfu daotan decoction,Xiehe yin,Erchen decoction),formula for regulating blood circulation and removing stasis(Gexia zhuyu decoction,Huatan tongmai yin)]can alleviate inflammatory response,improve abnormal glucose and lipid metabolism,and enhance ovarian function by inhibiting NF-κB signaling pathway,thus improving PCOS.