儿童甲状腺毒症病因及临床特征分析

Analysis of etiology and clinical characteristics of thyrotoxicosis in children

目的分析儿童甲状腺毒症病因及临床特征。方法选取我院2016年1月至2022年3月就诊的65例甲状腺毒症患儿,按照病因将其分为Graves病(GD)患儿及非GD患儿,收集患儿的病史资料,分析疾病的临床特征。结果65例甲状腺毒症患儿中,GD 57例(87.69%),非GD 8例(12.31%)。GD与非GD患儿的年龄、青春期、男生、发热、甲状腺疼痛、促甲状腺激素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、四碘甲状腺原氨酸(T4)、三碘甲状腺原氨酸(T3)、促甲状腺素受体抗体(TRAb)阳性、甲状腺弥漫性肿大、超敏C反应蛋白(hs-CRP)增高占比比较,差异具有统计学意义(P<0.05)。结论儿童甲状腺毒症病因复杂,部分临床特征对于GD与非GD的鉴别诊断具有一定价值。

Objective To analyze the etiology and clinical characteristics of thyrotoxicosis in children.Methods Sixty-five children with thyrotoxicosis who were treated in our hospital from January 2016 to March 2022 were selected and divided into Graves'disease(GD)children and non-GD children according to the etiology.The medical history data of the children were collected and the clinical characteristics of the disease were analyzed.Results Among the 65 children with thyrotoxicosis,57 cases(87.69%)were GD and 8 cases(12.31%)were non-GD.There were statistically significant differences in the age,proportion of puberty,male,fever,thyroid pain,thyroid stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine(FT3),tetraiodothyronine(T4),triiodothyronine(T3),positive thyrotrophin receptor antibody(TRAb),diffuse goiter enlargement and increased high-sensitive C-reactive protein(hs-CRP)between GD and non-GD children(P<0.05).Conclusion The etiology of thyrotoxicosis in children is complex,and some clinical features have certain value for the differential diagnosis of GD and non-GD.