穴位推拿联合布地奈德+特布他林雾化吸入治疗支气管哮喘患儿的效果及对炎症因子水平的影响

Effect of acupoint massage combined with budesonide+terbutaline atomization inhalation in the treatment of children with bronchial asthma and its influence on the levels of inflammatory factors

目的探讨穴位推拿联合布地奈德+特布他林雾化吸入治疗支气管哮喘患儿的效果及对炎症因子水平的影响。方法选取2021年1月至2022年1月收治的64例支气管哮喘患儿,采用随机数字表法将其分为A组(32例,布地奈德+特布他林雾化吸入治疗)和B组(32例,在A组基础上实施穴位推拿)。比较两组的治疗效果。结果治疗后,两组的喘息、呼吸困难、咳嗽及肺部湿啰音评分降低,且B组低于A组(P<0.05)。治疗后,两组的儿童哮喘控制测试问卷(C-ACT)评分、第1秒用力呼气容积占预计值的百分比(FEV1%)、最大呼气峰流速度占预计值的百分比(PEF%)高于治疗前(P<0.05);治疗后,B组的C-ACT评分、FEV1%和PEF%高于A组(P<0.05)。治疗后,两组的嗜酸性粒细胞(EOS)计数及免疫球蛋白E(IgE)、神经营养因子-3(NT-3)水平低于治疗前(P<0.05);治疗后,B组的EOS计数及IgE、NT-3水平低于A组(P<0.05)。随访6个月,两组的哮喘复发率无显著差异(P>0.05)。结论穴位推拿联合布地奈德+特布他林雾化吸入治疗支气管哮喘患儿的效果显著,可改善临床症状和肺功能,降低炎症因子水平,值得临床推广应用。

Objective To explore the effect of acupoint massage combined with budesonide+terbutaline atomization inhalation in the treatment of children with bronchial asthma and its influence on the levels of inflammatory factors.Methods A total of 64 children with bronchial asthma admitted from January 2021 to January 2022 were selected and divided into group A(32 cases,budesonide+terbutaline atomization inhalation treatment)and group B(32 cases,acupoint massage on the basis of the group A)by random number table method.The therapeutic effects of the two groups were compared.Results After treatment,the scores of wheezing,dyspnea,cough and lung moist rales in the two groups decreased,and those in the group B were lower than the group A(P<0.05).After treatment,the Childhood Asthma Control Test(C-ACT)score,percentage of predicted value of forced expiratory volume in the first second(FEV1%)and percentage of predicted value of peak expiratory flow(PEF%)in the two groups were higher than those before treatment(P<0.05);after treatment,the C-ACT score,FEV1%and PEF%in the group B were higher than those in the group A(P<0.05).After treatment,the eosinophilic(EOS)count and the levels of immunoglobulin E(IgE)and neurotrophin-3(NT-3)of the two groups were lower than those before treatment(P<0.05);after treatment,the EOS count and the levels of IgE and NT-3 in the group B were lower than those in the group A(P<0.05).Follow up for 6 months,there was no significant difference in the recurrence rate of asthma between the two groups(P>0.05).Conclusion Acupoint massage combined with budesonide+terbutaline atomization inhalation is effective in the treatment of children with bronchial asthma,it can improve clinical symptoms and lung function and reduce the levels of inflammatory factors.It is worthy of chinical promotion and application.