肠道菌群紊乱与围术期神经认知障碍相关性的研究进展

Advances research in correlation between gut microbiota disturbance and perioperative neurocognitive disorders

围术期神经认知障碍(PND)是围术期常见的中枢神经系统并发症。临床上PND的诊断与治疗手段匮乏,发生率居高不下,其机制与干预手段已经成为围术期未来研究方向之一。目前研究表明,肠道菌群紊乱可能通过微生物群-肠-脑轴参与PND的发生发展。本文从围术期多种因素影响肠道菌群组成、肠道菌群参与PND的潜在机制、特定菌群预测PND的发生发展及预防干预措施等方面进行综述,以期为保障围术期脑健康提供新理念。

Perioperative neurocognitive disorders(PND)is a common central nervous system complication during the perioperative period.The diagnosis and treatment methods for PND are scarce,and the incidence rate remains high.The pathogenesis and treatment of PND have become one of the future research directions in the perioperative period.Currently,the research shows that disturbance of gut microbiota may be involved in the occurrence and development of PND through the microbiota-gut-brain axis.This article reviews the multiple factors affecting gut microbiota composition during perioperative period,the potential mechanisms of dysbiosis participating in PND,the prediction of the occurrence and development of PND by specific microbiota,and corresponding preventive interventions,so as to provide new concepts for perioperative brain health.