贝克曼uniCelDxI 800化学发光仪检测CYFRA21-1、CA72-4、CA50及NSE在结肠息肉及结肠癌鉴别诊断中的价值

Value of CYFRA21-1,CA72-4,CA50 and NSE Detected by Beckman uniCelDxI 800 Chemiluminescence Apparatus in Differential Diagnosis of Colon Polyps and Colon Cancer

目的:研究分析贝克曼uniCelDxI 800化学发光仪检测NSE、CA50、CA72-4以及CYFRA21-1鉴别诊断结肠癌与结肠息肉的临床价值。方法:研究对象为医院2022年9月~2023年9月收治的结肠癌和结肠息肉患者100例,均行CA50、CYFRA21-1、NSE以及CA72-4检测,以结肠镜病理检查结果为金标准,运用受试者工作特征(ROC)曲线对各个指标鉴别诊断结肠息肉与结肠癌的价值进行分析。结果:与结肠息肉组比较,结肠癌组的NSE、CA50、CA72-4以及CYFRA21-1水平均较高,组间对比有差异(P<0.05);结肠癌组的CA72-4、NSE、CYFRA21-1以及CA50单一和联合检测阳性率均比结肠息肉组高(P<0.05);血清NSE、CA50、CA72-4以及CYFRA21-1的ROC曲线分析AUC值分别为0.804、0.899、0.838、0.939,并且可以将NSE>16.80ng/mL、CA50>13.00U/mL、CA72-4>6.66U/mL以及CYFRA21-1>4.60ng/mL作为结肠癌的鉴别诊断标准。结论:临床上在鉴别诊断结肠癌和结肠息肉时,通过运用贝克曼uniCelDxI 800化学发光仪对CA50、CYFRA21-1、NSE以及CA72-4进行检测,可以发挥辅助诊断效果,具有一定的应用价值。

Objective:To study the clinical value of detecting NSE,CA50,CA72-4 and CYFRA21-1 with Beckman uniCelDxI 800 chemiluminescence apparatus in differential diagnosis of colon cancer and colon polyp.Methods:A total of 100 patients with colon polyp and colon cancer admitted to the hospital from September 2022 to September 2023 were selected as the study objects,and CA50,CYFRA21-1,NSE and CA72-4 were detected.Colonoscopy pathological examination results were used as the gold standard.Receiver operating characteristic(ROC)curve was used to analyze the value of each index in the differential diagnosis of colon polyp and colon cancer.Results:Compared with colon polyp group,the levels of NSE,CA50,CA72-4 and CYFRA21-1 in colon cancer group were higher,and there were significant differences between groups(P<0.05).The positive rates of CA72-4,NSE,CYFRA21-1 and CA50 in colon cancer group were higher than those in colon polyp group(P<0.05).Meanwhile,according to ROC curve analysis,the AUC values of serum NSE,CA50,CA72-4 and CYFRA21-1 in the diagnosis of colon cancer were 0.804,0.899,0.838 and 0.939,respectively.NSE>16.80ng/mL,CA50>13.00U/mL,CA72-4>6.66U/mL and CYFRA21-1>4.60ng/mL could be used as differential diagnostic criteria for colon cancer.Conclusion:In the differential diagnosis of colon cancer and colon polyps,the detection of CA50,CYFRA21-1,NSE and CA72-4 by using Bekeman uniCelDxI 800 chemiluminescence instrument can play an auxiliary diagnostic effect and has certain application value.