增强型体外反搏联合稳斑贴治疗难治性心绞痛的临床疗效

Clinical Efficacy of Enhanced External Counterpulsation Combined with Stable Patch Therapy for the Treatment of Refractory Angina

目的:探讨增强型体外反搏联合稳斑贴对难治性心绞痛的临床疗效。方法:选取2018年1月—2021年3月于河南中医药大学第一附属医院住院治疗的难治性心绞痛病人80例作为研究对象,按照随机数字表法分为试验组和对照组,每组40例。对照组给予常规药物治疗,试验组在对照组治疗基础上加用增强型体外反搏和稳斑贴。观察两组治疗前后心绞痛发作次数、心绞痛疼痛程度、硝酸甘油使用量、生活质量、焦虑状态、内皮微颗粒水平。结果:治疗后,两组心绞痛发作次数、视觉模拟评分法(VAS)评分及硝酸甘油使用量降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组健康相关生存质量量表(SF-12)评分较治疗前升高,且高于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组汉密尔顿焦虑量表(HAMA)评分较治疗前降低,且低于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组内皮微颗粒水平较治疗前降低,且低于对照组,差异均有统计学意义(P<0.05)。结论:增强型体外反搏联合稳斑贴能够有效缓解难治性心绞痛病人的临床症状,提高病人生活质量水平,其机制可能与改善血管内皮功能、增加心肌灌注和冠脉血流储备,进而缓解心绞痛症状有关。

Objective:To exploring the clinical efficacy of enhanced external counterpulsation(EECP)combined with stable patch therapy for the treatment of refractory angina.Methods:Eighty patients with refractory angina were divided into experimental group and control group according to random number table method,with 40 cases in each group.The control group was treated with conventional drugs,and the experimental group received the EECP and stable patch therapy on the basis of conventional drugs.The number of angina attacks,degree of angina pain,dosage of nitroglycerin tablets,quality of life,anxiety status,and endothelial microparticle levels between the two groups were observed before and after treatment.Results:After treatment,the number of angina attacks,visual analogue scale(VAS)score and nitroglycerin consumption in 2 groups decreased,and the experimental group were lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the score of health related Quality of Life Scale(SF-12)in experimental group was higher than that before treatment,and higher than that in control group,with statistical significance(P<0.05).After treatment,the score of Hamilton Anxiety Scale(HAMA)in the experimental group was lower than that before treatment,and lower than that in the control group,with statistical significance(P<0.05).After treatment,the level of endothelial microparticles in experimental group was lower than that before treatment,and lower than that in control group,with statistical significance(P<0.05).Conclusion:Enhanced external counterpulsation combined with stable patch could effectively relieve the clinical symptoms and improve the quality of life of patients with refractory angina pectoris.The mechanism may be related to improving vascular endothelial function,increasing myocardial perfusion and coronary blood flow reserve,and thus alleviating the attack of angina pectoris.