逍遥丸辅助治疗对肝郁脾虚症乙肝患者肝功能及乙肝标志物转阴率的影响

Effect of Xiaoyao Pills Adjuvant Therapy on the Liver Function of Hepatitis B Patients with Liver Depression and Spleen Deficiency and the Negative Rate of Hepatitis B Markers

目的探讨肝郁脾虚症乙肝患者采用逍遥丸辅助治疗的效果。方法随机将漳州市中医院2022年1月至2023年7月收治的肝郁脾虚症乙肝患者80例分为两组,各40例。对照组采用恩替卡韦治疗,基于此,观察组加用逍遥丸治疗,均治疗3个月,比较两组治疗效果、肝功能、乙肝标志物转阴率及不良反应。结果与对照组治疗总有效率77.50%(31/40)比较,观察组治疗总有效率95.00%(38/40)更高(P<0.05);治疗后,两组的总胆红素(TBIL)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)及丙氨酸基转移酶(ALT)水平均降低,且观察组更低(P<0.05);观察组乙肝表面抗原(HBsAg)、乙肝病毒脱氧核酸(HBV-DNA)、乙肝e抗原(HBeAg)转阴率均比对照组高(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论肝郁脾虚症乙肝患者采用逍遥丸辅助治疗效果显著,可改善肝功能,提高乙肝标志物转阴率,且有较高的安全性。

Objective To investigate the effect of xiaoyao pills in the adjuvant treatment of liver depression and spleen deficiency in hepatitis B patients.Methods 80 cases of hepatitis B patients with liver depression and spleen deficiency admitted to the Zhangzhou Hospital of Traditional Chinese Medicine from January 2022 to July 2023 were randomly divided into 2 groups,40 cases each.The control group was treated with entecavir,based on this,the observation group was treated with xiaoyao pills for 3 months,and the therapeutic effect,liver function,the rate of hepatitis B markers turning negative and adverse reactions were compared between the two groups.Results Compared with the control group,the total effective rate was 77.50%,and the observation group 95.00%was higher(P<0.05).After treatment,the levels of total bilirubin(TBIL),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and alanine transferase(ALT)in 2 groups were decreased,and those in observation group were lower(P<0.05).The negative conversion rates of hepatitis B surface antigen(HBsAg),hepatitis B virus deoxydna(HBV-DNA)and e antigen(HBeAg)in observation group were higher than those in control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Xiaoyao pills can improve liver function and increase the negative conversion rate of hepatitis B markers with high safety.