帕利哌酮、哌罗匹隆治疗对男性精神分裂症患者的临床疗效及对血清泌乳素水平的影响

The Clinical Efficacy of Paliperidone and Perospirone in the Treatment of Male Schizophrenia Patients and Its Impact on Serum Prolactin Levels

目的比较帕利哌酮、哌罗匹隆治疗男性精神分裂症患者的临床疗效及对血清泌乳素水平的影响。方法选取2020年1月至2023年1月在宜春市第三人民医院进行治疗的男性精神分裂症患者70例,根据入院时间将研究对象随机分为治疗A组和治疗B组,各35例。治疗A组采用帕利哌酮进行治疗,治疗B组采用哌罗匹隆进行治疗。比较帕利哌酮、哌罗匹隆治疗男性精神分裂症患者的临床疗效及对血清泌乳素水平的影响。结果治疗后,两组PANSS评分各项以及总分均有所降低;与治疗B组相比较,治疗A组评分较低,差异有统计学意义(P<0.05)。治疗后,与治疗B组相比较,治疗A组体重增加发生情况较高,静坐不能发生情况较低,差异有统计学意义(P<0.05)。治疗后,与治疗前相比较,治疗A组泌乳素较高,差异有统计学意义(P<0.05)。结论帕利哌酮和哌罗匹隆两种药物对男性精神分裂者均能有效地控制精神障碍类疾病,使患者的精神状态及症状得到极大程度的改善,降低患者不良情绪(如焦虑、抑郁)的发生,不良反应小。而帕利哌酮对于抗精神病类疾病阳性症状与阴性症状改善能力更强,但其极易出现体重波段增高和泌乳素表达上升的现象。

Objective To compare the clinical efficacy and impact on serum prolactin levels of paliperidone and perospirone in the treatment of male schizophrenia patients.Methods Seventy male patients with schizophrenia who underwent treatment in Yichun Third People's Hospital from January 2020 to January 2023 were selected.According to the admission time,the study subjects were randomly divided into treatment group A and treatment group B,with 35 patients in each group.Treatment group A was treated with paliperidone,while treatment group B was treated with perospirone.Compare the clinical efficacy and impact on serum prolactin levels of paliperidone and perospirone in the treatment of male schizophrenia patients.Results After treatment,the PANSS scores and total scores of patients in both group decreased,compared with treatment group B,the PANSS scores in treatment group A were lower,and the difference was statistically significant(P<0.05).After treatment,compared with Group B,Group A had a higher incidence of weight gain and a lower incidence of inability to sit still,the difference was significant(P<0.05).After treatment,compared with before treatment,the prolactin levels in treatment group A were higher,and statistically significant differences were observed(P<0.05).Conclusion Both paliperidone and perospirone can effectively control mental disorders in male schizophrenics,greatly improving their mental state and symptoms,reducing the occurrence of adverse emotions such as anxiety and depression.The adverse reactions is low.Paliperidone has a stronger ability to improve positive and negative symptoms of antipsychotic diseases,but it is highly susceptible to increased body weight and prolactin expression.