临床药师参与宫颈癌根治性放化疗患者营养支持的效果分析

Effect Analysis of Clinical Pharmacists Participating in Nutritional Support for Patients with Radical Radiotherapy and Chemotherapy for Cervical Cancer

目的观察临床药师对改善宫颈癌同期放化疗患者的营养状况及放化疗耐受的效果。方法选取赣州市肿瘤医院2021年1月至2023年9月收治的初诊为宫颈癌且接受根治性放化疗的患者116例,对照组临床药师不参与营养监护,观察组均由临床药师对其全程营养监护,比较两组患者的营养相关指标的变化以及放化疗耐受情况。结果对照组较观察组中重度营养不良发生率更高,差异有统计学意义(P=0.006)。观察组有9例放疗中断,放疗完成49例(84.48%);对照组22例放疗中断,完成36例(62.07%),两组比较差异有统计学意义(t=7.44,P=0.006)。结论在宫颈癌同步放化疗期间临床药师给与全程营养监护能够改善患者的营养状况及提高患者对放化疗的耐受性。

Objective Observing the effect of clinical pharmacists on improving the nutritional status and chemotherapy tolerance of cervical cancer patients undergoing concurrent radiotherapy and chemotherapy.Methods 116 patients with initial diagnosis of cervical cancer and receiving curative radiotherapy and chemotherapy were selected from Ganzhou Cancer Hospital from January 2021 to September 2023.The control group of patients had no involvement of clinical pharmacists in nutritional monitoring,while the observation group of patients had full nutritional monitoring by clinical pharmacists.The changes in nutritional indicators and radiotherapy and chemotherapy tolerance of the two groups of patients were compared.Results The incidence of severe malnutrition in the control group was higher than that in the observation group,with a statistical difference(P=0.006);9 patients in the observation group experienced radiotherapy interruption,and 49 patients(84.48%)completed radiotherapy;22 patients in the control group experienced radiotherapy interruption,and 36 cases(62.07%)were completed.The difference between the two groups was statistically significant(t=7.44,P=0.006),indicating that the observation group had better tolerance to radiotherapy and chemotherapy.Conclusion During synchronous radiotherapy and chemotherapy for cervical cancer,clinical pharmacists providing full nutritional monitoring can improve the patient's nutritional status and enhance their tolerance to radiotherapy and chemotherapy.