纤溶酶注射液联合醋酸泼尼松片对突发性耳聋患者血液流变学及炎性因子水平的影响

Effects of Fibrinogenase Injection Combined with Prednisone Acetate Tablets on Hemorheology and Inflammatory Factors in Patients with Sudden Deafness

目的研究纤溶酶注射液联合醋酸泼尼松片治疗突发性耳聋对患者血液流变学及炎性因子水平的影响。方法以配对原则收集2021年11月至2023年11月南阳市第一人民医院104例突发性耳聋患者,按不同治疗方案分为对照组(醋酸泼尼松片治疗)、联合组(纤溶酶注射液+醋酸泼尼松片治疗),各52例。治疗10 d后,比较两组疗效,不良反应发生率,不同频率听阈值,血液流变学[全血低切黏度(LBV)、全血高切黏度(HBV)、血细胞比容(HCT)、血浆黏度(PV)],炎性因子[白细胞介素-1β(IL-1β)、IL-6]及凋亡蛋白[半胱氨酸天冬氨酸蛋白酶3(Caspase-3)、p53蛋白]水平。结果联合组总有效率较对照组高(94.23%>80.77%)(P<0.05);治疗后联合组0.5 kHz、1 kHz、2 kHz听阈值低于对照组(P<0.05);治疗后联合组LBV、HBV、HCT、PV、IL-1β、IL-6、Caspase-3、p53蛋白低于对照组(P<0.05);两组不良反应发生率(7.69%vs 11.54%)相比,差异无统计学意义(P>0.05)。结论纤溶酶注射液联合醋酸泼尼松片治疗突发性耳聋安全有效,可抑制炎性反应及听毛细胞凋亡,改善血液流变学,有效降低纯音听阈值。

Objective To study the effects of fibrinogenase injection combined with prednisone acetate tablets on hemorheology and inflammatory factors in patients with sudden deafness.Methods A total of 104 patients with sudden deafness in The First People's Hospital of Nanyang from November 2021 to November 2023 were retrospectively collected,and the patients were divided into control group(prednisone acetate tablets treatment)and combination group(fibrinogenase injection+prednisone acetate tablets treatment)according to different treatment plans,52 cases each.After 10 days of treatment,the efficacy,incidence of adverse reactions,different frequency hearing thresholds,hemorheology[whole blood low tangential viscosity(LBV),whole blood high tangential viscosity(HBV),hematocrit(HCT),plasma viscosity(PV)],inflammatory factors[interleukin-1β(IL-1β),IL-6]and apoptotic protein[cysteine aspartic proteinase-3(Caspase-3),p53 protein]levels of the two groups were compared.Results The total effective rate of the combination group was higher than that of the control group(94.23%>80.77%)(P<0.05).After treatment,the hearing thresholds of 0.5 kHz,1 kHz and 2 kHz in the combination group were lower than those in the control group(P<0.05).After treatment,the proteins of LBV,HBV,HCT,PV,IL-1β,IL-6,Caspase-3 and p53 in combination group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(7.69%vs 11.54%)(P>0.05).Conclusion Fibrinogenase injection combined with prednisone acetate tablets is safe and effective in the treatment of sudden deafness,which can inhibit inflammatory response and apoptosis of auditory hair cells,improve hemorheology,and effectively reduce pure tone hearing threshold.