西替利嗪联合鼻负压置换治疗小儿上气道咳嗽综合征的疗效观察

Observation the Therapeutic Effect of Cetirizine Combined with Nasal Negative Pressure Replacement in the Treatment of Upper Airway Cough Syndrome in Children

目的探讨小儿上气道咳嗽综合征通过西替利嗪联合鼻负压置换治疗的临床疗效。方法选取2021年12月至2022年8月信丰县妇幼保健院收治的94例上气道咳嗽综合征的患儿,按信封随机法将其分为试验组(47例)、对照组(47例)。对照组施行西替利嗪治疗,试验组施行西替利嗪联合鼻负压置换治疗,比较两组疗效、症状积分、炎性反应和不良反应等。结果试验组总有效率(95.74%)高于对照组(82.98%)(P<0.05)。治疗2周后,两组咳嗽、咽部黏液附着和流涕等症状积分下降,且试验组咳嗽、咽部黏液附着和流涕等症状积分低于对照组(P<0.05)。治疗2周后,两组各项炎性反应指标下降,且试验组白细胞介素(IL)-1、干扰素-γ(IFN-γ)和IL-8指标低于对照组(P<0.05)。两组头晕乏力、鼻出血与腹泻等不良反应率对比差异无统计学意义(P>0.05)。结论在小儿上气道咳嗽综合征疾病的治疗中,鼻负压置换联合西替利嗪治疗的疗效显著,有助于改善患儿咳嗽与咽部黏液附着症状,减轻炎性反应水平,且不良反应较少。

Objective Exploring the value of cetirizine combined with nasal negative pressure replacement therapy for upper airway cough syndrome(UACS)in children.Methods 94 patients with UACS admitted to Xinfeng County Maternal and Child Health Hospital from December 2021 to August 2022 were selected and randomly divided into an experimental group(47 cases)and a control group(47 cases)using the envelope method.The control group received cetirizine treatment,while the experimental group received cetirizine combined with nasal negative pressure replacement treatment.The efficacy,symptom scores,inflammatory reactions,and adverse reactions of the two groups were compared.Results The total effective rate of the experimental group was 95.74%higher than that of the control group,which was 82.98%(P<0.05).After 2 weeks of treatment,the scores of symptoms such as cough,pharyngeal mucus attachment,and runny nose decreased in both groups,and the experimental group was lower than that in the control group(P<0.05).After 2 weeks of treatment,both groups showed decrease in inflammatory response indicators,and the experimental group interleukin-1,interferon-γ(IFN-γ)and the IL-8 index were lower than the control group(P<0.05).There was no difference in the total incidence of adverse reactions such as dizziness,fatigue,nosebleed,and diarrhea between the two groups(P>0.05).Conclusion In the treatment of UACS in children,the combination of nasal negative pressure replacement and cetirizine has a significant therapeutic effect,which helps to improve the symptoms of cough and pharyngeal mucus adhesion,reduce the level of inflammatory reactions,and have fewer adverse reactions.