不同剂量地佐辛复合丙泊酚在无痛肠镜检查中的应用效果分析

Analysis on Application Effect of Different Doses of Dezocine Combined with Propofol in Painless Colonoscopy

目的:探讨不同剂量地佐辛复合丙泊酚在无痛肠镜检查中的应用效果。方法:选取2022年9月—2023年9月于宜兴市官林医院实施无痛肠镜检查的患者150例作为研究对象,按照随机数字表法分为对照组和观察组,各75例。对照组给予高剂量地佐辛复合丙泊酚麻醉,观察组给予低剂量地佐辛复合丙泊酚麻醉。比较两组丙泊酚用量、术后苏醒时间、生命体征指标、不良反应发生情况。结果:观察组丙泊酚用量少于对照组,术后苏醒时间短于对照组,差异有统计学意义(P<0.001)。T_(0)、T_(1)、T_(3)、T_(4),两组平均动脉压(MAP)水平比较,差异无统计学意义(P>0.05);T2,观察组MAP水平低于对照组,差异有统计学意义(P<0.05);T_(2)、T_(3)、T_(4),对照组MAP水平高于T0,差异有统计学意义(P<0.05)。T_(0)、T_(1)、T_(2)、T_(3)、T_(4),两组心率(HR)水平比较,差异无统计学意义(P>0.05);T_(3)、T_(4),两组HR水平高于T0,差异有统计学意义(P<0.05)。T_(0)、T_(4),两组经皮动脉血氧饱和度(SpO_(2))水平比较,差异无统计学意义(P>0.05);T_(1)、T_(2)、T_(3),对照组SpO_(2)水平高于T0及同期观察组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.025)。结论:低剂量地佐辛复合丙泊酚在无痛肠镜麻醉患者中的临床应用效果较好,麻醉和镇痛效果显著,能够减轻患者的痛苦和不适感,维持其生命体征,且安全性较高。

Objective:To explore the application effect of different doses of dezocine combined with propofol in painless colonoscopy.Methods:A total of 150 patients who underwent painless colonoscopy at Guanlin Hospital of Yixing City from September 2022 to September 2023 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 75 patients in each group.The control group received high-dose dezocine and propofol for anesthesia,and the observation group received low-dose dezocine and propofol for anesthesia.The propofol dosage,postoperative awakening time,vital sign indicators,and occurrence of adverse reactions were compared between the two groups.Results:The dosage of propofol in the observation group was less than that in the control group,the postoperative awakening time in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.001).There was no significant difference in the MAP level between the two groups at T_0,T_1,T_(3and) T_4(P>0.05).At T_2,the MAP level in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).At T_2,T_(3and) T_4,the MAP level in the control group was higher than that at T_0,and the difference was statistically significant(P<0.05).At T_0,T_1,T_2,T_(3and) T_4,there was no significant difference in the HR level between the two groups(P>0.05).At T_(3and) T_4,the HR level in two groups was higher than that at T_0,and the difference was statistically significant(P<0.05).At T_(3and) T_4,there was no significant difference in SpO_(2level) between the two groups(P>0.05).At T_1,T_(2and) T_3,the SpO_(2level) in the control group was higher than that at T_(0and) that in the observation group during the same period(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.025).Conclusion:The clinical application effect of low-dose dezocine combined with propofol in painless colonoscopy anesthesia patients is good,with significant anesthesia and analgesia effects,which can relieve the pain and discomfort of patients,maintain their vital signs,and have high safety.