SARC-F筛查肌少症效能的优化研究

A study on optimization of SARC-F screening efficacy for sarcopenia

目的探讨SARC-F筛查肌少症效能的优化方法。方法2018年3月—2021年8月,采用SARC-F评分量表、AWGS2和EWGSOP2诊断共识对受试者进行肌少症诊断,分析诊断一致性,优化SARC-F筛查肌少症的效能。结果以SARC-F、AWGS2和EWGSOP2诊断的肌少症患病率分别为12.78%(52/407)、28.26%(115/407)和31.20%(127/407)。以AWGS2和EWGSOP2为金标准,SARC-F≥4分筛查肌少症的灵敏度为37.39%(43/115)和35.43%(45/127),特异度为96.92%(283/292)和97.50%(273/280)。受试者操作特征曲线显示,SARC-F的最优诊断截断值为2分。SARC-F≥2分筛查肌少症的灵敏度为89.57%(103/115)和88.98%(113/127),特异度为76.71%(224/292)和79.29%(222/280)。结论SARC-F≥2分诊断肌少症可能具有更高的灵敏度,更适用于初步筛查。

Objective To explore an optimization method of SARC-F screening efficacy for sarcopenia.Methods From March 2018 to August 2021,the SARC-F scoring scale,Asian Working Group for Sarcopenia 2(AWGS2)and European Working Group on Sarcopenia in Older People 2(EWGSOP2)were used to diagnose sarcopenia in the subjects.Results The prevalence of sarcopenia diagnosed by SARC-F,AWGS2 and EWGSOP2 were 12.78%(52/407),28.26%(115/407)and 31.20%(127/407),respectively.Taking AWGS2 and EWGSOP2 as the gold criteria,the sensitivity of SARC-F≥4 for screening sarcopenia was 37.39%(43/115)and 35.43%(45/127),and the specificity was 96.92%(283/292)and 97.50%(273/280).Receiver operator characteristic curve showed that the optimal cut-off value of SARC-F was 2 points.The sensitivity of SARC-F≥2 for screening sarcopenia was 89.57%(103/115)and 88.98%(113/127),and the specificity was 76.71%(224/292)and 79.29%(222/280).Conclusion SARC-F≥2 may have higher sensitivity for diagnosing sarcopenia and is more suitable for initial screening.