新生儿中大型血管瘤5例报告

Medium and large neonatal hemangioma:report of 5 cases

目的分析新生儿中、大型血管瘤(IH)的临床特征和诊疗方法,以期为临床提供参考。方法选择2018年2月-2022年2月黄冈市中心医院新生儿科收治的5例IH患儿,回顾性分析其临床特征、治疗方法和效果。结果病例1、5合并卡梅现象,采用普萘洛尔联合糖皮质激素、长春新碱、西罗莫司治疗。病例2、4合并心功能不全,病例2采用普萘洛尔联合糖皮质激素、长春新碱、西罗莫司治疗;病例4于第三天放弃治疗,当日死亡。病例3应用西罗莫司治疗。随访,与同龄儿相比,存活4例者其身高、体重、器官功能均良好。结论对新生儿中大型IH,西罗莫司与激素、长春新碱短期联合应用,疗效安全,耐受性好。

Objective To analyze the clinical features and diagnosis and treatment of medium and large infant hemangioma(IH)in order to provide clinical reference.Methods From February 2018 to February 2022,5 children with IH were selected from the neonatology Department of Huanggang Central Hospital.The clinical features,treatment and response were analyzed retrospectively.Results Cases 1 and 5 patients with Kasabach-Merritt Phenomenon were treated with propranolol combined with glucocorticoids,vincristine and sirolimus.Cases 2 and 4 were combined with cardiac dysfunction,and case 2 was treated with propranolol combined with glucocorticoids,vincristine,and sirolimus.Case 4 abandoned treatment on the third day and died on the same day.Case 3 was treated with Sirolimus.Follow-up:4 of the 5 children survived,and compared with children of the same age,their height,weight and organ function were all in good condition.Conclusions For medium and large IH,Sirolimus combined with hormone and vincristine for short term,the efficacy is safe and well tolerated.