短链氯化石蜡在海洋环境中的分布及生态毒理效应

Distribution and toxicological effects of short-chained chlorinated paraffins in the marine environment

短链氯化石蜡(Short-chain chlorinated paraffin,SCCPs)受工业活动及季风气候影响,在中国海洋环境中的分布总体上呈现沿岸大于深海。由于其具有较高的亲脂性和疏水性,极易在生物体内聚集,并可通过食物网传递产生生物放大效应。此外,大量的毒理研究表明,SCCPs主要通过代谢紊乱、氧化应激、内分泌失调及与生物大分子结合等机制,对生物体产生潜在的发育毒性、肝毒性、内分泌紊乱以及神经毒性等。在未来还需借助组学等技术分析完善SCCPs的潜在毒性,通过更多的体外实验分析其在人体的暴露风险。

The distribution of short-chained chlorinated paraffins(SCCPs)in China's marine environment is predominantly coastal rather than deep-sea,influenced by industrial activities and the monsoon climate.Due to their high lipophilicity,and hydrophobicity,they are highly susceptible to aggregate in organisms and can undergo trophic amplification through food web transfer.In addition,a large number of toxicological studies have shown that SCCPs have potential developmental toxicity,hepatotoxicity,endocrine disruption,and neurotoxicity on organisms through metabolic disorders,oxidative stress,endocrine disruption and binding to biomolecules.In the future,it is necessary to analyze the potential toxicity of SCCPs with the help of histology and other techniques and to assess the risk of human exposure through increasing in vitro experiments.