响应面法优化糖精生产新工艺及产物分析

Optimization of New Process and Product Analysis of Saccharin Production by Response Surface Methodology

研究以传统的苯酐法生产糖精过程为基础,对糖精生产工艺中的氨化反应,采用去甲苯的工艺条件,用环保溶剂水替代有机溶剂。在单因素优化的基础上,通过响应面优化法,建立相关的实验模型,分析了对反应影响较大的温度、配比和反应时间等参数之间的交互作用的影响以及对产品收率的影响。经优化后的最佳的工艺条件为n(氨水)∶n(2-甲氧羰基苯磺酰氯)=4∶1,反应温度为73.94℃,反应时间为31.80 min,此条件下糖精收率为88.85%。优化后的工艺条件不仅减少了甲苯等有机溶剂在生产过程中的风险,而且新生产工艺的反应条件温和相比与甲苯溶剂下的生产条件收率也有所提高。

The study was based on the traditional process of producing saccharin by the phthalic anhydride method,and the ammonification reaction in the saccharin production process was carried out by using the process conditions of de-toluenization and replacing organic solvents with environmentally friendly solvent water.Based on the single-factor optimization,a relevant experimental model was established by response surface optimization method to analyze the degree of influence of the interaction between parameters such as temperature,proportioning and reaction time,which have a large influence on the reaction,and the effect on the product yield.The optimized process conditions were n(ammonia)∶n(2-methoxycarbonylbenzenesulfonyl chloride)=4∶1,the reaction temperature was 73.94℃,the reaction time was 31.80 min,and the yield of saccharin was 88.85%under this condition.The optimized process conditions not only reduced the risk of organic solvents such as toluene in the production process,but also improved the yield under mild reaction conditions compared with the production conditions under toluene solvent.