神经阻滞联合普瑞巴林治疗带状疱疹性神经痛的临床有效性

Clinical Efficacy of Nerve Block Combined with Pregabalin in the Treatment of Postherpetic Neuralgia

目的探究神经阻滞(NB)联合普瑞巴林治疗带状疱疹性神经痛(PHN)的临床有效性。方法选取2022年4月-2023年8月于都县人民医院收治的76例PHN患者,行随机数字表法分为对照组(38例)与观察组(38例),对照组给予普瑞巴林治疗,观察组应用NB联合普瑞巴林治疗。比较两组临床疗效、治疗前后的疼痛程度[数字疼痛评分(NRS)]、炎症水平[白细胞介素-10(IL-10)、白细胞介素-26(IL-26)]与免疫应答指标[高迁移率族蛋白b1(HMGB1)、趋化因子CXC配体10(CXCL10)]。结果观察组临床总有效率(97.37%)高于对照组(84.21%)(P<0.05);两组治疗后NRS评分均低于治疗前,且观察组NRS评分低于对照组(P<0.05);两组治疗后IL-10、IL-26水平低于治疗前,且观察组IL-10、IL-26水平低于对照组(P<0.05);两组治疗后HMGB1、CXCL10水平低于治疗前,且观察组HMGB1、CXCL10水平低于对照组(P<0.05)。结论NB联合普瑞巴林治疗PHN效果肯定,可缓解患者疼痛,下调其体内炎症反应,改善机体免疫应答。

Objective To explore the clinical efficacy of nerve block(NB)combined with pre gabalin in the treatment of posthertic neuralgia(PHN).Methods A total of 76 patients with PHN admitted to Duxian People's Hospital from April 2022 to August 2023 were randomly divided into control group(38 patients)and observation group(38 patients).The control group was treated with pregabalin,and the observation group was treated with NB combined with pregabalin.The clinical efficacy,pain degree[digital pain score(NRS)],inflammation level[interleukin-10(IL-10),interleukin-26(IL-26)]and immune response indexes[high mobility group protein b1(HMGB1),chemokine CXC ligand 10(CXCL10)]before and after treatment were compared between the two groups.Results The total effective rate of the observation group(97.37%)was higher than that of the control group(84.21%)(P<0.05).After treatment,the NRS score of the two groups was lower than that before treatment,and the NRS score of the observation group was lower than that of the control group(P<0.05).After treatment,the levels of IL-10 and IL-26 in the two groups were lower than those before treatment,and the levels of IL-10 and IL-26 in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of HMGB1 and CXCL10 in the two groups were lower than those before treatment,and the levels of HMGB1 and CXCL10 in the observation group were lower than those in the control group(P<0.05).Conclusion NB combined with pregabalin is effective in the treatment of PHN,which can relieve the pain of patients,down-regulate the inflammatory response in vivo and improve the immune response of the body.