血清视锥蛋白样蛋白1、铁调素25预测急性缺血性脑卒中患者静脉溶栓治疗预后的临床价值

Clinical value of serum VILIP⁃1 and Hepc25 in predicting prognosis of patients with acute ischemic stroke after intravenous thrombolysis

目的分析血清视锥蛋白样蛋白1(trypanoid-likeprotein1,VILIP-1)、铁调素25(Hepc25)预测急性缺血性脑卒中(acute ischemic stroke,AIS)患者静脉溶栓治疗预后的临床价值。方法选225例医院2022年1月至2023年11月诊治急性缺血性脑卒中患者,据Rankin量表(m RS)分组,mRS≥3分为预后不良组97例、mRS<3分为预后良好组128例。对比患者血清VILIP-1、Hepc25水平及对静脉溶栓治疗预后价值。结果经logistic回归分析,年龄、入院血糖、LYM、NIHSS评分、PLT、WBC、VILIP-1、Hepc25均是AIS患者预后影响的因素(P<0.05);与轻度缺损相比,中度和重度缺损患者VILIP-1、Hepc25水平上升;与中度缺损相比,重度缺损患者VILIP-1、Hepc25水平增高;而与预后不良组相比,预后良好组VILIP-1、Hepc25水平下降,差异有统计学意义(P<0.05);ROC曲线分析,VILIP-1、Hepc25单项诊断低于联合诊断(P<0.05)。结论VILIP-1、Hepc25水平增高,参与了患者静脉溶栓治疗过程,影响患者预后,可作为AIS患者预后诊断的临床指标。

Objective The clinical value of serum VILIP-1 and Hepc25 in predicting the prognosis of patients with Acute ischemic stroke(AIS)from intravenous thrombolysis was analyzed.Methods A total of 225 patients with acute ischemic stroke diagnosed and treated in the hospital from January 2022 to November 2023 were selected.According to Rankin Scale(mRS)grouping study,97 patients with mRS≥3 were divided into poor prognosis group and 128 patients with mRS<3 were divided into good prognosis group.The serum levels of VILIP-1 and Hepc25 were compared and their prognostic value for intravenous thrombolysis.Results After logistic regres-sion analysis,age,admission blood glucose,LYM,NIHSS score,PLT,WBC,VILIP-1,and Hepc25 were all factors affecting the prognosis of AIS patients(P<0.05);VILIP-1 and Hepc25 levels increased in patients with moderate and severe defects compared with mild defects.VILIP-1 and Hepc25 levels were higher in patients with severe defects than those with moderate defects.Compared with the poor prognosis group,the VILIP-1 and Hepc25 levels in the good prognosis group were decreased,with statistical difference(P<0.05).ROC curve analysis showed that single diagnosis of VILIP-1 and Hepc25 was lower than combined diagnosis(P<0.05).Conclusion The elevated levels of VILIP-1 and Hepc25 participate in the process of intravenous thrombolysis and affect the prognosis of patients,and can be used as clinical indicators for the prognosis of AIS patients.