妊娠剧吐相关因素分析及其对妊娠结局的影响

Factors Influencing Hyperemesis Gravidarum and Its Impact on Pregnancy Outcome

目的:探讨妊娠剧吐(hyperemesis gravidarum,HG)的危险因素,并分析HG对不同妊娠合并症发生和妊娠结局的影响。方法:采用回顾性研究,选取2019年至2022年襄阳市第一人民医院174例出现HG的孕妇为HG组,同时选取此时间内174例无恶心呕吐等早孕反应的孕妇作为无HG组。采用Logistic回归分析影响HG发生的相关危险因素,比较两组妊娠合并症和妊娠结局发生情况。结果:职业状态(OR=1.979,95%CI:1.225~3.196)和妊娠期出血史(OR=2.140,95%CI:1.300~3.521)是影响HG发生的相关因素;两组孕妇妊娠合并症发生情况组间差异无统计学意义(P>0.05);HG组胎盘厚度明显低于无HG组(P=0.045);HG组早产儿发生率明显高于无HG组(P=0.018)。结论:孕妇职业状态和妊娠期出血与HG发生风险密切相关。HG对胎盘厚度和早产有潜在影响,临床上应及时给予HG孕妇针对性的预防及干预措施。

Objective To explore the risk factors of hyperemesis gravidarum(HG)and analyze its influence on the occur⁃rence of different pregnancy complications and outcomes.Methods A retrospective study was conducted.A total of 174 pregnant women with HG in Xiangyang No.1 People′s Hospital from 2019 to 2022 were selected as the HG group,and 174 pregnant women without early pregnancy reactions such as nausea and vomiting as the HG-free group.Logistic regression was used to analyze the associated risk factors affecting the occurrence of HG,and the pregnancy complications and out⁃comes between the two groups were compared.Results Occupation(OR=1.979,95%CI:1.225~3.196)and history of bleeding during pregnancy(OR=2.140,95%CI:1.300~3.521)were related factors for the occurrence of HG.There was no difference in the incidence of pregnancy complications between the two groups(P>0.05).Placental thickness in the HG group was lower than that in the HG-free group(P=0.045).The incidence of preterm births in the HG group was higher than that in the HG-free group(P=0.018).Conclusion The occupation of pregnant women and bleeding during pregnancy are closely related to the occurrence of HG.HG has a potential impact on placental thickness and preterm delivery,and thus timely targeted preventive and intervention measures should be given to pregnant women with HG in clinical practice.