自拟润肺膏合穴位贴敷治疗肺脾气虚型尘肺病临床研究

Clinical study on self-made runfei ointment combined with acupoint application in the treatment of pneumoconiosis of lung-spleen Qi deficiency type

目的:观察自拟润肺膏合穴位贴敷治疗肺脾气虚型尘肺病的临床疗效。方法:选取70例肺脾气虚型尘肺病患者,随机分为对照组和实验组各35例。对照组采用西医常规治疗及健康教育,实验组在对照组治疗基础上口服自拟润肺膏配合穴位贴敷治疗,两组疗程均为14 d。结果:治疗后,两组患者肺功能指标[用力肺活量占预计值百分比(FVC%pred)、第1秒用力呼气容积占预计值百分比(FEV1%pred)、FEV1/FVC]均较治疗前改善(P<0.05),但两组间各指标比较无显著性差异(P>0.05)。两组患者治疗后血清C反应蛋白(CRP)水平、中医症状(喘息、咳嗽、乏力、腹胀)评分、慢性阻塞性肺疾病评估测试(COPD assessment test,CAT)评分均较治疗前下降(P<0.05),实验组各指标水平明显低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后6 min步行试验(6 MWT)距离均较治疗前长(P<0.05),实验组6 MWT距离明显长于对照组,差异有统计学意义(P<0.05)。结论:自拟润肺膏配合穴位贴敷治疗肺脾气虚型尘肺病可明显改善患者的临床症状,减轻炎症反应,提高运动耐力。

Objective:To observe the clinical effect of self-made runfei ointment combined with acupoint applica⁃tion in the treatment of pneumoconiosis of lung-spleen Qi deficiency type.Methods:A total of 70 patients with pneu⁃moconiosis of lung and spleen Qi deficiency type were randomly divided into control group and experimental group.The control group was treated with routine western medicine treatment and health education.The experimental group was treated with self-made runfei ointment combined with acupoint application on the basis of the control group.The course of treatment in both groups was 14 days.Results:After treatment,the pulmonary function indexes[Forced vital capaci⁃ty as a percentage of predicted value(FVC%pred),forced expiratory volume in the first second as a percentage of predicted value(FEV1%pred),FEV1/FVC]of the two groups were improved compared with those before treatment(P<0.05).Upon comparison of various indicators between the two groups,no significant defferences were noted(P>0.05).After treatment,the levels of C-reactive protein(CRP),TCM symptoms(wheezing,cough,fatigue,abdominal distension)scores and chronic obstructive pulmonary disease assessment test(COPD assessment test,CAT)scores in the two groups were lower than those before treatment(P<0.05).The indexes in the experimental group were signifi⁃cantly lower than those in the control group,and the differences were statistically significant(P<0.05).The 6-min⁃ute walking test(6 MWT)distance of the two groups after treatment was longer than that before treatment(P<0.05),and the 6 MWT distance of the experimental group was significantly longer than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Self-made runfei ointment combined with acupoint application in the treatment of pneumoconiosis of lung-spleen Qi deficiency type can significantly improve the clinical symptoms of pa⁃tients,reduce inflammation and improve exercise endurance.