透明质酸相关受体及其介导的功能

Hyaluronic acid-related receptors and related functions

透明质酸(hyaluronic acid,HA)是一种由D-葡萄糖醛酸和N-乙酰葡糖胺交替连接而成的糖胺聚糖,是细胞外基质的主要成分之一,在体内发挥调节细胞增殖、黏附、迁移,调节机体炎症反应、增强免疫应答等作用。与细胞表面的HA受体结合是HA对细胞产生作用的重要途径,不同相对分子质量的HA与同一HA受体的作用方式不同,而相同相对分子质量的HA与不同HA受体作用后产生的效果亦不相同。因此,HA的不同生物学功能可能与其相对分子质量大小、结合的受体类型及与受体的结合方式有关。目前已发现的可与HA结合的受体有CD44、TLRs、RHAMM、HARE、LYVE1及LAYN等,本文将对上述透明质酸受体及其介导的功能进行综述。

Hyaluronic acid(HA)is a glycosaminoglycan composed of alternating D-glucuronic acid and Nacetylglucosamine.HA is one of the main components of the extracellular matrix,and plays an important role in regulating cell proliferation,adhesion,migration,inflammation and immune response in vivo.Binding to the HA receptor on the cell surface is an important way for HA to exert an effect on cell.HA of different molecular weights interacts differently with the same HA receptor,and HA of the same molecular weight can produce different effects when interacting with different HA receptors.Therefore,the diverse biological functions of HA may be related to its molecular weight,the type of receptors it binds to,and the manner of binding with these receptors.The receptors that have been identified to bind to HA include CD44,TLRs,RHAMM,HARE,LYVE1 and LAYN.This work provides a comprehensive review of the aforementioned HA receptors and their related functions.