可注射富血小板纤维蛋白在治疗颞下颌关节紊乱病中的应用

Application of injectable platelet-rich fibrin in the treatment of temporomandibular joint disorders

慢性颞下颌关节紊乱病患者通常伴有持续疼痛及身体、行为、社会心理症状,需要有效的治疗手段恢复其下颌功能并控制疼痛。随着生物补充概念的提出,血浆基质制品在关节疾病治疗中逐渐开始流行,成为了再生治疗的核心方法之一。该文主要介绍了可注射富血小板血浆纤维蛋白的应用特点和作用机制,分析多项研究报道的有关注射型富血小板纤维蛋白对于颞下颌关节紊乱病患者的疼痛控制、张口度改善以及关节形态恢复效果;提出现阶段临床试验中存在的差异如血浆基质制品离心方案不同、注射次数差异,以及疾病分型选择等,为可注射富血小板纤维蛋白在颞下颌关节紊乱病治疗领域的研究和应用提供参考。

Chronic temporomandibular joint disorders(TMD)patients usually suffer from persistent pain and physical,behavioral,psychological,and social symptoms.Effective control and treatment method are needed to restore their jaw function and manage pain.With the concept of biosupplementation proposed,plasma matrix products have gradually become popular in articular disease treatment and have become one of the core method of regenerative therapy.This paper mainly introduces the application characteristics and action mechanism of injectable platelet-rich plasma fibrin.It analyzes several research reports on the effect of injectable platelet-rich fibrin on pain control,mouth opening improvement and joint morphology restoration in TMD patients.It proposes that differences exist in current clinical trials such as different centrifugation schemes for plasma matrix products,injection times,and disease classification selection,providing a reference for the research and application of injectable platelet-rich fibrin in the treatment of TMD.