重塑巨噬细胞的肿瘤治疗策略

Tumor treatment strategies involving the remodeling of macrophages

肿瘤微环境(tumor microenvironment,TME)能够诱导巨噬细胞分化,在不同微环境下巨噬细胞可分化为经典活化型(M1型)和替代活化型(M2型),而大量活化的巨噬细胞浸润肿瘤间质,被称为肿瘤相关巨噬细胞(tumorassociated macrophages,TAMs)。目前普遍认为,M1型TAMs具有激活机体肿瘤免疫的功能,起到抗肿瘤的作用;而M2型TAMs可抑制肿瘤免疫,发挥促肿瘤作用。通过耗竭M2型巨噬细胞或重塑巨噬细胞的极性可以达到肿瘤免疫治疗的目的。然而,耗竭巨噬细胞可能会促进肿瘤细胞的免疫逃逸,因此重塑巨噬细胞在肿瘤免疫治疗领域显示出更大的潜力。本文综述了重塑巨噬细胞用于肿瘤治疗的最新相关研究进展。

The tumor microenvironment(TME) can induce macrophage differentiation, in which macrophages can differentiate into classical activated type(M1 phenotype) and alternative activated type(M2 phenotype), and a large number of activated macrophages infiltrate the tumor strome, which is called tumor-associated macrophages(TAMs). At present, it is generally believed that M1 TAMs could activate tumor immunity and play an anti-tumor role, while M2 TAMs could inhibit tumor immunity and promote tumor progress. Therefore, the purpose of tumor immunotherapy can be achieved by depleting M2 macrophages or remodeling the polarity of macrophages. However, depleting macrophages may promote the immune escape of tumor cells, and remodeling the polarity of macrophage has shown greater potential in tumor immunotherapy. This paper reviews the updated research progress on the use of remodeled macrophages in cancer therapy.