参附注射液联合针刺外治法治疗感染性休克的临床观察

Clinical observation on the treatment of infectious shock with Shenfu Injection combined with acupuncture external therapy

[目的]观察参附注射液联合针刺外治法对感染性休克患者的影响。[方法]将筛选出的感染性休克患者66例随机分为对照组和观察组,各33例,两组均予以常规西医综合治疗,观察组联合应用参附注射液及针刺外治法,两组均连续治疗7天。比较两组患者治疗前后炎性损伤指标、氧代谢指标(氧合指数、中心静脉血氧饱和度、静-动脉二氧化碳分压差、血乳酸)变化;比较两组血管活性药物使用时间、早期目标指导性复苏治疗(EGDT)达标时间及28 d病死率。[结果]治疗后观察组的降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、血乳酸水平及静-动脉二氧化碳分压差均低于对照组,差异有统计学意义(P<0.05);观察组氧合指数、中心静脉血氧饱和度均高于对照组,差异有统计学意义(P<0.05);治疗后两组白细胞介素-1(IL-1)水平差异无统计学意义(P>0.05);治疗后观察组血管活性药物使用时间、早期目标指导性复苏治疗(EGDT)达标时间及28 d病死率均低于对照组,差异有统计学意义(P<0.05)。[结论]在感染性休克早期治疗中应用参附注射液联合针刺外治法可以有效降低炎症反应,改善组织缺氧,缩短血管活性药物使用时间,降低病死率。

[Objective]Observe the effect of Shenfu Injection combined with acupuncture external treatment on patients with septic shock.[Methods]Randomly divide the 66 selected patients with infectious shock into two groups:a control group and an observation group,with 33 cases in each group.Both groups received routine Western medicine comprehensive treatment.Observation group combined application of Shenfu Injection and acupuncture external treatment method.Both groups were treated continuously for 7 days.Compare the changes in inflammatory injury indicators including procalcitonin(PCT),C-reactive protein(CRP),interleukin-1(IL-1),interleukin-6(IL-6),oxygen metabolism indicators(oxygen sum index,central venous oxygen saturation,static arterial carbon dioxide partial pressure difference,blood lactate)before and after treatment between two groups of patients.Compare the use time of two groups of vasoactive drugs,the target time for early targeted resuscitation therapy(EGDT),and the 28-day mortality rate.[Results]After treatment,the observation group had lower levels of PCT,CRP,IL-6,blood lactate,and arterial carbon dioxide partial pressure difference compared to the control group,and the differences were statistically significant(P<0.05).The oxygen and index and central venous oxygen saturation in the observation group were all higher than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the levels of IL-1 between the two groups after treatment(P>0.05).After treatment,the observation group had significantly lower use time of vasoactive drugs,EGDT target time,and 28-day mortality rate compared to the control group(P<0.05).[Conclusion]The application of Shenfu Injection combined with acupuncture external treatment in the early treatment of infectious body disease can effectively reduce inflammatory reactions,improve tissue hypoxia,shorten the use time of vasoactive drugs,and reduce mortality.