钛表面钛酸钡纳米棒阵列构建及超声抗菌性能研究

Preparation and ultrasound-assisted antibacterial properties ofbarium titanate nanorod arrays on titanium

钛植入物术后细菌感染是临床上常见的并发症。通过水热处理和退火处理,在Ti表面构建了缺氧钛酸钡纳米棒(BaTiO_(3-x))阵列。采用扫描电子显微镜、透射电子显微镜、X射线衍射仪证实了BaTiO_(3)纳米棒的合成,采用X射线光电子能谱确认了氧空位的存在。以甲基紫(MV)为捕获剂验证了BaTiO_(3-x)纳米棒阵列在超声下的活性氧(ROS)产生能力。结果表明BaTiO_(3-x)纳米棒阵列在超声波(US)辐照下可有效产生羟基自由基(·OH)。抗菌实验表明,BaTiO_(3-x)纳米棒阵列超声作用15 min对金黄色葡萄球菌(S.aureus)展现出优良抗菌能力,抗菌率达到90.92%。研究为钛植入体表面超声响应抗菌涂层的制备提供了思路。

Postoperative bacterial infection of titanium implants is a common clinical complication.In this paper,arrays of oxygen-deficient barium titanate nanorods(BaTiO_(3-x))were constructed on the Ti surface by hydrothermal and annealing treatments.The synthesis of BaTiO 3 nanorods was confirmed using scanning electron microscopy,transmission electron microscopy,and X-ray diffractometry,and the presence of oxygen vacancies was confirmed using X-ray photoelectron spectroscopy.The reactive oxygen species(ROS)generation ability of BaTiO_(3-x) nanorod arrays under ultrasound was verified using methyl violet(MV)as a trapping agent.The results show that BaTiO_(3-x) nanorod arrays can effectively generate hydroxyl radicals(·OH)under ultrasonic(US)irradiation.Antibacterial experiments were conducted with Staphylococcus aureus(S.aureus),and the antibacterial capacity of BaTiO_(3-x) nanorod arrays under US was investigated by the plate spread method.The results showed that the antibacterial rate of BaTiO 3-x against S.aureus reached 90.92% after 15 min of US irradiation.This study provides ideas for the preparation of antimicrobial coatings on titanium implant surfaces and lays the foundation for expanding US-responsive antimicrobial coatings.