急性缺血性脑卒中患者血清NSE、hs-CRP水平与脑梗死体积、NIHSS评分的关系及临床指导意义

Relationship Between Serum NSE and hs-CRP Levels and Brain Infarct Volume and NIHSS Score in Patients with Acute Ischemic Stroke and Its Clinical Significance

目的探索急性缺血性脑卒中(acute ischemic stroke,AIS)患者血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、超敏C反应蛋白(high sensitivity c-reactive protein,hs-CRP)水平与脑梗死体积、美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分的相关性。方法选取2019年4月至2023年4月武威市凉州医院收治的80例AIS患者为研究组,同时选取同期来院进行体检的50例健康者作为观察组。比较AIS组和健康组血清NSE、hs-CRP水平;不同脑梗死体积和NIHSS评分者血清NSE、hs-CRP水平;AIS患者NSE、hs-CRP水平与脑梗死体积、NIHSS评分相关性。结果AIS组患者血清NSE和hs-CRP水平均显著高于健康对照组(P<0.001)。中体积梗死组和大体积梗死组患者NSE、hs-CRP水平均显著高于小体积梗死组(P<0.001);大体积梗死组患者NSE、hs-CRP水平均显著高于中体积梗死组(P<0.001)。NIHSS评分中度组和重度组患者NSE、hs-CRP水平均显著高于轻度组(P<0.001);重度组患者NSE、hs-CRP水平均显著高于中度组(P<0.001)。Pearson分析发现AIS患者NSE、hs-CRP水平与脑梗死体积及NIHSS评分均呈正相关。结论随着梗死面积的增大和神经功能受损程度的增加,AIS患者血清hs-CRP、NSE水平呈上升趋势。

Objective Exploring the correlation between levels of serum neuron specific enolase(NSE)and high-sensitivity C-reactive protein(hs-CRP)with volume of cerebral infarction and NIHSS score in patients with acute ischemic stroke(AIS).Methods 80patients with AIS treated at Liangzhou Hospital in Wuwei City from April 2019 to April 2023 were selected as the study group,and 50 healthy individuals undergoing physical examinations at the same period were selected as the control group.The levels of serum NSE and hs-CRP in the AIS group were compared with those in the healthy group.The serum NSE and hs-CRP in patients with different volumes of cerebral infarction and NIHSS scores were compared.The correlation between the levels of serum NSE and hs-CRP in AIS patients and the volume of cerebral infarction and NIHSS score was analyzed.Results The levels of serum NSE and hs-CRP in the AIS group were significantly higher than those in the healthy control group(P<0.001).The levels of serum NSE and hs-CRP in patients with medium and large volume infarctions were significantly higher than those in patients with small volume infarction(P<0.001);the levels of serum NSE and hs-CRP in patients with large volume infarction were significantly higher than those in the patients with medium volume infarction(P<0.001).The levels of serum NSE and hs-CRP in patients with moderate and severe NIHSS scores were significantly higher than those in patients with mild NIHSS(P<0.001);the levelsof serum NSE and hs-CRP in patients with severe NIHSS were significantly higher than those in patients with moderate NIHSS(P<0.001).Pearson analysis showed that serum NSE and hs-CRP levels in AIS patients were positively correlated with the volume of cerebral infarction and NIHSS score.Conclusion With the increase in infarct size and degree of neurological impairment,serum hs-CRP and NSE levels in patients with AIS showed an upward trend.