盐酸司来吉兰中两种致突变杂质的合成方法与含量测定

Synthesis Method and Content Determination of Two Mutagenic Impurities in Selegiline Hydrochloride

药物杂质是影响药物质量的重要因素,尤其是致突变杂质。盐酸司来吉兰中潜在存在两种新型的致突变杂质,探索了它们的合成方法并在药物中测定其含量,确定了它们的控制策略。

Drug impurities are important attributes that affect drug quality,especially mutagenic impurities.There are two potential new types of mutagenic impurities in selegiline hydrochloride.We explore their synthesis methods and determine their content in the drug to determine their control strategies.