小儿川崎病合并冠状动脉病变的危险因素

Risk factors of coronary artery lesions in children with Kawasaki disease

目的分析小儿川崎病合并冠状动脉病变的危险因素。方法2021年10月-2023年6月宜春市人民医院收治的川崎病患儿80例,参考有无冠状动脉合并性病变进行冠状动脉病变组(28例)与非冠状动脉病变组(52例)划分。经回顾分析法,对患儿一般人口学特征(年龄、性别、临床症状等)及可能造成患儿并发冠状动脉病变的危险因素(如性别、感染因素等)进行调查,以统计学软件进行统计分析,以Logistic回归分析技术为基础,对冠状动脉合并性病变的危险因素加以分析。结果经单因素分析,两组性别、发热时间、肺炎支原体、EB病毒、巨细胞病毒、肺炎链球菌及丙种球蛋白无反应情况比较差异有统计学意义(P<0.05);Logistic多因素回归分析结果显示,冠状动脉合并性病变的危险因素为男性、发热时间(P<0.05)。结论导致川崎病患儿发生冠状动脉合并性病变的危险因素较为复杂,需加强该类患儿的重点照护,采取有效措施干预,促进患儿病情转归,为患儿预后改善提供支持。

OBJECTIVE To analyze the effect of risk factors of pediatric Kawasaki disease complicated with coronary artery lesions.METHODS A total of 80 children with Kawasaki disease admitted to Yichun People's Hospital from Oct 2021 to Jun 2023 were divided into the coronary artery disease group(28 cases)and the non-coronary artery disease group(52 cases)according to whether the concomitant coronary artery lesions occurred.The general demographic characteristics(age,gender,clinical symptoms,etc.)and potential risk factors(such as gender,infec-tion factors,etc.)for coronary artery disease were investigated by retrospective analysis.Statistical software was used for statistical analysis,and logistic regression analysis was used to analyze the ralated risk factors of coronary artery disease.RESULTS Univariate analysis showed that there were significant differences in gender,fever time,mycoplasma pneumoniae,EB virus,cytomegalovirus,streptococcus pneumoniae and gamma globulin between the two groups(P<0.05).According to the results of logistic multiple regression analysis,the independent risk fac-tors for coronary artery comorbidities included male gender,fever duration≥7,etc.(P<0.05).CONCLUSION The risk factors that lead to coronary artery complications in children with Kawasaki disease are relatively com-plex.It is necessary to strengthen the focus of care for such children,take effective measures to intervene,pro-mote the recovery of their condition,and provide support for the improvement of their prognosis.