临床药师处理多重耐药腹腔感染患者不良反应的实践体会

Practice Experience of Clinical Pharmacists in Managing Adverse Drug Reactions in Patients with Intra-Abdominal Infection Caused by Multi-Drug Resistant Bacteria

目的:探讨多重耐药菌腹腔感染患者在使用高剂量替加环素引起凝血功能障碍时,临床药师在参与制定治疗方案及处理不良反应过程中的作用。方法:回顾性分析临床药师参与1例多重耐药菌腹腔感染患者的抗感染治疗过程,并总结处理高剂量替加环素引起不良反应的处理经验。该患者先后接受多种抗菌药物治疗,治疗期间出现了凝血功能异常等不良反应,临床药师通过详细分析患者病情、用药情况等,判断凝血功能异常与替加环素有关,并建议医生调整治疗方案。结果:按照临床药师的个体化用药建议,该患者在停用替加环素和调整治疗方案后,凝血功能逐渐恢复,感染最终得到有效控制,病情好转出院。结论:临床药师与医护人员密切合作,积极参与患者抗感染治疗方案制定,并提供药学监护及跟踪随访,提高患者依从性,保障了患者用药安全,对进一步改善多重耐药腹腔感染患者的治疗效果具有积极的意义。

Objective:To explore the role of clinical pharmacists in formulating treatment regimen and managing adverse reactions in the case of coagulation disorder caused by high-dose tigecycline in patients with intra-abdominal infection caused by multi-drug resistant bacteria.Methods:The anti-infective treatment of a patient with intraperitoneal infection with multidrug-resistant bacteria was retrospectively analyzed,and the experience of dealing with adverse reactions caused by high-dose tigecycline was summarized.The clinical pharmacist judged that the abnormal coagulation function was related to tigecycline through a detailed analysis of the patient's condition and medication,and recommended the doctor to adjust the treatment plan.Results:According to the individualized medication recommendations of the clinical pharmacist,the patient discontinued tigecycline,adjusted the treatment regimen,gradually recovered the coagulation function,and the infection was finally effectively controlled,and the patient was discharged from the hospital with improvement.Conclusion:Close cooperation between clinical pharmacists and healthcare professionals,active participation in the formulation of anti-infective treatment regimen for patients,and pharmaceutical care and follow-up can improve the patient compliance and guarantee their medication safety,which is of positive significance for further improving the therapeutic effect in patients with intra-abdominal infection caused by multi-drug resistant bacteria.