铁死亡在类风湿关节炎进展中的作用

Research Progress of Ferroptosis in Rheumatoid Arthritis

铁死亡是一种新型细胞死亡途径,其机制与细胞内铁蓄积与脂质过氧化造成的细胞损伤有关。铁死亡可以通过诱导免疫紊乱、促进滑膜炎症、引起血管内皮细胞增殖、加剧软骨侵蚀和骨破坏等方式,参与并影响RA的发生发展。因此,通过干预铁死亡,可以影响RA的病理过程,改善患者的临床症状,降低致残风险。

Ferroptosis is a newly discovered pathway of apoptosis,which mechanism is related to cell damage caused by intracellular iron accumulation and lipid peroxidation.Ferroptosis can participate in and affect the occurrence and development of RA by inducing immune disorders,promoting synovial inflammation,causing vascular endothelial cell proliferation as well as aggravating cartilage erosion and bone destruction.From this prospect,the pathological process of RA can be affected by intervening in Ferroptosis so as improve the clinical symptoms of patients and reduce the risk of disability.