中药单体调控NF-κB信号通路治疗脊髓损伤的研究进展

Research Progress of Traditional Chinese Medicine Monomer Intervention NF-κB Pathway in Treating Spinal Cord Injury

核转录因子-κB(nuclear transcription factor-κB,NF-κB)信号通路与脊髓损伤密切相关,多种中药单体及其有效成分能够靶向NF-κB信号通路治疗脊髓损伤,如黄酮类、酚类、萜类、苷类及皂苷类化合物等,其主要作用机制为抑制脊髓损伤后的炎症反应、氧化应激及细胞凋亡,加快脊髓组织及少突、轴突及髓鞘的再生,促进运动功能的恢复。NF-κB信号通路或可成为脊髓损伤治疗的潜在靶点。但目前NF-κB信号通路机制复杂,与多条通路协同作用,而现有研究多针对单一通路,今后需进一步探讨多条通路协同治疗脊髓损伤的机制,同时加强体内外实验验证,明确中药作用靶点,研制安全靶向药物,为脊髓损伤的临床治疗和新药研发提供参考。

The nuclear transcription factor-κB(NF-κB)signaling pathway is closely related to spinal cord injury,and a variety of traditional Chinese medicine monomers and their active ingredients can target the NF-κB signaling pathway to treat spinal cord injury,such as flavonoids,phenols,terpenoids,glycosides and saponins,etc.,and its main mechanism of action is to inhibit inflammation,oxidative stress and apoptosis after spinal cord injury,and accelerate the regeneration of spinal cord tissues and oligodends,axons and myelin sheaths.Promotes recovery of motor function.The NF-κB signaling pathway may be a potential target for the treatment of spinal cord injury.In the future,it is necessary to further explore the mechanism of multiple pathways in the synergistic treatment of spinal cord injury,strengthen the in vivo and in vivo experimental verification,clarify the targets of traditional Chinese medicine,and develop safe targeted drugs,to provide a reference for the clinical treatment of spinal cord injury and the research and development of new drugs.