非小细胞肺癌脑转移全脑放疗患者联合同步或序贯推量的疗效对比

Comparison on efficacy of whole brain radiotherapy combined with synchronous or sequential thrust in patients suffering from non-small cell lung cancer complicated with brain metastases

目的 对于非小细胞肺癌脑转移行全脑放疗的患者,联合同步或序贯推量两种放疗方式进行疗效对比。方法 回顾性分析2017年1月—2021年12月本院肿瘤放疗科收治的非小细胞肺癌脑转移全脑放疗患者125例的临床资料,分为同步组(68例)和序贯组(57例)两组。两组患者分别采用全脑放疗联合同步推量和全脑放疗联合序贯推量,通过对比两组患者不良反应发生情况及生存期长短,不同方式的全脑放疗并不会导致患者复发部位出现明显的差异进行疗效对比。结果 两组患者均顺利完成治疗,无严重不良反应发生,对于急性及晚期不良反应,两组患者发生率差异无统计学意义(P>0.05)。在总生存期和无进展生存期的结果上,两组患者具有统计学差异(P<0.05),同步组优于序贯组。结论 对于非小细胞肺癌脑转移行全脑放疗的患者,不良反应发生率相当,而生存期方面联合同步推量较序贯推量略有优势。

Objective To compare the efficacy of whole brain radiotherapy combined with two radiotherapy modes of simultaneous or sequential dose on patients suffering from brain metastases of non-small cell lung cancer.Methods The clinical data of 125 patients suffering from brain metastases of non-small cell lung cancer who were admitted to the department of radiation oncology of the hospital from January 2017 to December 2021 were retrospectively analyzed,and they were divided into synchronous group(68 cases)and sequential group(57 cases).The two groups of patients were treated with whole-brain radiotherapy combined with simultaneous dose and whole-brain radiotherapy combined with sequential dose,respectively.The occurrence of adverse reactions and the length of survival of the two groups were compared to analyse their efficacy,and the results indicated that different types of whole brain radiotherapy will not result in difference in location of recurrence.Results The two groups of patients successfully completed the treatment,and no serious adverse reactions occurred.There was no significant difference in the incidence of acute and late adverse reactions between the two groups(P>0.05).There were significant differences in overall survival and progression-free survival between the two groups(P<0.05),and the synchronous group was superior to the sequential group.Conclusions For patients with brain metastases of non-small cell lung cancer who underwent whole-brain radiotherapy,the incidence of adverse reactions was significant,and the combined simultaneous dose had a slight advantage over the sequential dose in terms of survival.