多囊卵巢综合征表观遗传学发病机制的研究现状

Current status of epigenetic pathogenesis in polycystic ovary syndrome

多囊卵巢综合征(PCOS)是一种常见且复杂的内分泌代谢性疾病之一,影响全球大约5%~20%的育龄女性,极大影响患者的生活质量。PCOS的发病机制涉及遗传和环境危险因素的交互作用,其中包括种族、遗传背景、生活方式等多种因素。近年来,表观遗传学在PCOS发病机制研究中的作用日益受到关注,特别是在DNA甲基化、非编码RNA表达变化和组蛋白修饰等方面的研究取得了重要进展。通过探究PCOS发病机制与表观遗传学之间的关系可以为降低不孕率、提高女性生活质量提供新思路。

Objective Polycystic ovary syndrome(PCOS)is a common and complex endocrine-metabolic disorder affecting approximately 5-20%of women of reproductive age globally,significantly impacting their quality of life.The etiology of PCOS is influenced by the interplay of genetic and environmental risk factors,including ethnicity,genetic predisposition,lifestyle,and other elements.In recent years,the role of epigenetics in the pathogenesis of PCOS has garnered increasing interest,with significant advancements in research on DNA methylation,alterations in non-coding RNA expression,and histone modifications.Investigating the link between PCOS pathogenesis and epigenetics offers new perspectives for reducing infertility rates and enhancing the quality of life for women.