黄酮类化合物抗鼻咽癌作用机制的研究进展

Research progress on the mechanism of flavonoids′anti nasopharyngeal carcinoma effect

鼻咽癌是一种好发于鼻咽部黏膜上皮的恶性肿瘤,具有易复发、早期易转移和恶性程度高等特点。目前,临床上治疗鼻咽癌主要以放疗或者化疗为主,但其引起的不良反应如腹泻、脱发等,严重影响患者的生活质量。此外,耐药性的产生是晚期鼻咽癌治疗失败的主要原因。黄酮类化合物具有良好的抗肿瘤、抗炎和抗氧化活性。近年来,在鼻咽癌防治机制方面的研究表明,黄酮类化合物可抑制鼻咽癌细胞增殖,诱导鼻咽癌细胞凋亡,调控鼻咽癌信号转导通路并有效增加对鼻咽癌的放疗和化疗敏感性。本文就黄酮类化合物防治鼻咽癌的作用机制研究进展作简要综述,为后续深入研究及临床合理应用,提供更多的科学依据和思路。

Nasopharyngeal carcinoma(NPC)is a malignant tumor that develops in the mucosal epithelium of the nasopharynx and is characterized by easy recurrence,early metastasis and high degree of malignancy.At present,clinical treatment of NPC is mainly based on radiotherapy or chemotherapy,but it causes adverse reactions such as diarrhea and hair loss,which seriously affect the quality of life of patients.The emergence of drug resistance is the main reason for the treatment failure of advanced NPC.Flavonoids belong to the secondary metabolites of plants and have good activities such as anti-tumor,anti-inflammatory and anti-oxidant.In recent years,studies on the mechanism of anti-NPC of flavonoids have gradually deepened and made significant progress.This mainly focuses on these aspects,in which flavonoids inhibit the proliferation of NPC cells,induce apoptosis of NPC cells,regulate the signaling pathway of NPC as well as increase the sensitivity of NPC to radiotherapy and chemotherapyt.This paper provides a brief review on the progress of research on the mechanism of action of flavonoids in the prevention and treatment of NPC,in order to provide more scientific ideas and bases for the subsequent in-depth research and rational clinical application.