生长抑素在肿瘤合并肠梗阻姑息治疗中的应用

Application of somatostatin in palliative treatment of tumor combined with intestinal obstruction

目的观察静脉持续泵入生长抑素在肿瘤合并肠梗阻姑息治疗中的应用效果。方法选取85例肿瘤合并肠梗阻患者为研究对象,随机分为两组。常规组42例予以胃肠减压治疗,试验组43例采用生长抑素辅助治疗。比较两组患者的胃肠动力、胃消化功能、炎症因子、免疫功能变化情况及恢复情况。结果在不同治疗方案下,试验组胃泌素(GAS)、胃动素(MLT)的水平均高于常规组,差异有统计学意义(P<0.05);试验组胃蛋白酶Ⅰ(PGⅠ)、胃蛋白酶Ⅱ(PGⅡ)的水平均高于常规组(P<0.05);试验组C-反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)的水平均低于常规组(P<0.05);试验组的T淋巴细胞CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)的水平均高于常规组(P<0.05);试验组的恢复自主进食时间、首次排气时间、首次排便时间、腹部不适缓解时间、住院时间均短于常规组(P<0.05)。结论经静脉持续泵入生长抑素能改善肿瘤合并肠梗阻患者的胃肠动力及胃消化功能,对缓解患者炎症反应、增强机体免疫力、加快康复进程均有积极意义。

Objective To observe the application effect of continuous intravenous infusion of somatostatin in the palliative treatment of patients with tumors and intestinal obstruction.Methods 85 patients with tumors and intestinal obstruction were selected as the study subjects and randomly divided into two groups.42 cases in the conventional group were treated with gastrointestinal decompression,while 43 cases in the experimental group were treated with somatostatin adjuvant therapy.The changes and recovery of gastrointestinal motility,gastric digestive function,inflammatory factors,and immune function were compare between two groups of patients.Results Under different treatment plans,the levels of gastrin(GAS)and motilin(MLT)in the experimental group were higher than those in the control group,showing a statistically significant difference(P<0.05);the levels of gastric protease I(PG I)and gastric proteaseⅡ(PGⅡ)in the experimental group were higher than those in the control group(P<0.05).The levels of C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6)in the experimental group were lower than those in the control group(P<0.05);the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in T lymphocytes in the experimental group were higher than those in the control group(P<0.05);the recovery time of autonomous eating,first exhaust time,first defecation time,abdominal discomfort relief time,and hospitalization time in the experimental group were all shorter than those in the conventional group(P<0.05).Conclusion Continuous intravenous infusion of somatostatin can improve the gastrointestinal motility and digestive function of patients with tumor complicated intestinal obstruction,and has a positive significance in alleviating inflammation,enhancing the body′s immune system,and accelerating the recovery process.