甲状腺癌中血清miR-150-5p表达水平与临床病理特征的关系

Expression level of miR-150-5p of thyroid cancer patients and its relationship with clinical pathological characteristics

目的探讨甲状腺癌组织miR-150-5p表达水平及对甲状腺癌鉴别诊断的辅助价值。方法选取82例甲状腺癌患者作为病理组,选取82例体检健康者作为对照组。比较甲状腺癌组织、血清中的miR-150-5p表达,分析组织、血清中的miR-150-5p表达与甲状腺癌患者临床特征的关系。结果甲状腺癌组织中miR-150-5p表达水平低于癌旁组织,差异具有统计学意义(P<0.05)。病例组血清中miR-150-5p水平低于对照组(P<0.05)。不同临床分期、分化程度、淋巴结转移、肿瘤直径情况的患者组织、血清中的miR-150-5p表达水平比较,差异有统计学意义(P<0.05)。组织中miR-150-5p表达与临床分期(r_(s)=-0.497)、淋巴结转移(r_(s)=-0.315)、肿瘤直径(r_(s)=-0.444)呈负相关(P<0.05);miR-150-5p表达与分化程度(r_(s)=0.404)呈正相关(P<0.05)。血清中miR-150-5p表达与临床分期(r_(s)=-0.455)、淋巴结转移(r_(s)=-0.306)、肿瘤直径(r_(s)=-0.433)呈负相关(P<0.05);miR-150-5p表达与分化程度(r_(s)=0.420)呈正相关(P<0.05)。结论甲状腺癌患者组织、血清中的miR-150-5p均呈低表达,其与临床分期、分化程度、淋巴结转移、肿瘤直径紧密相关。

Objective To investigate the expression level of miR-150-5p in tissues and serum of thyroid cancer tissues and to explore its auxiliary value for differential diagnosis of thyroid cancer.Methods 82 cases of thyroid cancer patients were selected(pathology group),and 82 cases of healthy people with physical examination were selected and set as the control group.The miR-150-5p expressions in the tissue and serum of thyroid cancer patients were compared,and the relationship between the miR-150-5p expressions in tissue and serum and the clinical characteristics of thyroid cancer patients was analyzed.Results The miR-150-5p expression level in thyroid cancer tissues was lower than that in paraneoplastic tissues,showing a statistically significant difference(P<0.05).Serum miR-150-5p level in the case group was lower than that in the control group(P<0.05).Comparison of tissue and serum miR-150-5p expression levels in patients with different clinical stages,differentiation degrees,lymph node metastasis,and tumor diameter conditions showed statistically significant differences(P<0.05).Tissue miR-150-5p expression was significant negative correlation(P<0.05)with clinical stage(r_(s)=-0.497),lymph node metastasis(r_(s)=-0.315),and tumor diameter(r_(s)=-0.444).The miR-150-5p expression was significant positive correlation(P<0.05)with differentiation degree(r=0.404).Serum miR-150-5p expression was significant negative correlation(P<0.05)with clinical stage(r_(s)=-0.455),lymph node metastasis(r_(s)=-0.306),and tumor diameter(r_(s)=-0.433).The miR-150-5p expression was significant positive correlation(P<0.05)with degree of differentiation(r_(s)=0.420).Conclusion The miR-150-5p shows low expression in tissue and serum of thyroid cancer,which is closely correlated with clinical stage,degree of differentiation,lymph node metastasis,and tumor diameter.