双水平连续正压通气治疗新生儿呼吸窘迫综合征的临床效果观察

Clinical Observation of Bi-level Ventilator CPAP in Treatment of Neonatal Respiratory Distress Syndrome

目的分析双水平连续正压通气(bi-level continuous positive airway pressure,BiPAP)治疗新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)的临床效果。方法选择2020年5月—2023年6月本院收治的80例NRDS患者作为研究对象,依据不同治疗方法将其分为对照组和观察组,每组40例。对照组采用正压通气治疗,观察组采用BiPAP治疗,全面评估并比较两组患者血流动力学、通气血气值。结果观察组在24h时点的平均动脉压显著低于对照组,而心率也显著低于对照组(P<0.05);在0和2h时点,两组平均动脉压和心率的差异不显著(P>0.05);观察组在2h和24h时点的动脉血氧分压、动脉血氧分压/吸入氧浓度比值显著高于对照组(P<0.05),而两组动脉血二氧化碳分压差异不显著(P>0.05)。结论BiPAP在治疗NRDS方面具有一定的优势,可以改善患者的氧合和通气情况。

Objective To analyze clinical effect of bi-level ventilator CPAP in treatment of neonatal respiratory distress syndrome.Methods The paper chose 80 patients with neonatal respiratory distress syndrome in the hospital from May 2020 to June 2023 as study subjects,and divided them into observation group and control group based on different treatment methods.Hemodynamics and ventilation blood gas values were comprehensively evaluated and compared between two groups.Results Average arterial pressure of observation group at 24 hours was significantly lower than control group,heart rate was significantly lower than control group(P<0.05).There was no significant difference in mean arterial pressure and heart rate between two groups at 0 and 2 hours.The arterial oxygen partial pressure and ratio of arterial oxygen partial pressure to inhaled oxygen concentration in observation group was significantly higher than control group at 2 and 24 hours(P<0.05),there was no significant difference in arterial carbon dioxide partial pressure.Conclusion BiPAP treatment can achieve certain advantages for neonatal respiratory distress syndrome,can improve oxygenation and ventilation conditions.