CalliSpheres载药微球动脉化疗栓塞与传统动脉化疗栓塞对不可切除肝内胆管细胞癌的疗效比较

Comparison between CalliSpheres drug loaded microsphere arterial chemoembolization and traditional arterial chemoembolization in therapeutic effect on unresectable intrahepatic cholangiocarcinoma

目的 比较Calli Spheres载药微球动脉化疗栓塞(DEB-TACE)与传统动脉化疗栓塞(C-TACE)治疗不可切除肝内胆管细胞癌的有效性和安全性。方法 选取丽水市人民医院2020年5月至2023年5月收治的肝内胆管细胞癌患者41例,通过随机数字表法分为DEB-TACE组(接受DEB-TACE治疗,21例)和C-TACE组(接受C-TACE治疗,20例)。治疗后4~6周,依据实体瘤疗效评估标准对患者的临床疗效进行评估,对比术后两组患者的不良事件发生情况,并对患者的生存情况进行随访。结果 DEB-TACE组患者的整体肿瘤客观反应率与C-TACE组相比(66.67%vs 50.00%),差异无统计学意义(χ^(2)=1.172,P=0.279),但是DEB-TACE组疾病控制率与C-TACE组相比(85.71%vs 55.00%),差异有统计学意义(χ^(2)=4.668,P=0.031)。DEB-TACE组患者的总生存期为(9.13±3.14)个月,长于C-TACE组的(6.06±2.37)个月,差异有统计学意义(t=3.520,P=0.001)。术后两组患者均未出现严重不良事件,两组的腹痛、发热、呕吐、肾功能障碍、腹股沟血肿等不良反应无差异(χ^(2)=2.783,P=0.095)。结论 Calli Spheres载药微球动脉化疗栓塞对于不可切除的肝内胆管细胞癌是一种安全、有效的治疗方法,其疗效优于传统动脉化疗栓塞。

Objective To conduct a comparison of the efficacy and safety of DEB-TACE utilizing CalliSpheres drugloaded microspheres versus conventional transarterial C-TACE in the treatment of unresectable intrahepatic cholangiocarcinoma.Methods A total of 41 patients with intrahepatic cholangiocarcinoma treated in Lishui People's Hospital from May 2020 to May 2023 were divided into the DEB-TACE group(received DEB-TACE,n=21)and the C-TACE group(received C-TACE,n=20)using a random number table method.Four to six weeks after treatment,the efficacy was evaluated based on the Response Evaluation Criteria in Solid Tumors(RECIST),the adverse events were compared between the two groups postoperatively and patient survival was followed up.Results There was no statistically significant difference in the overall tumor objective response rate between the two groups(66.67%vs 50.00%,χ^(2)=1.172,P=0.279).However,the disease control rate was remarkably higher in the DEB-TACE group than in the C-TACE group(85.71%vs 55.00%,χ^(2)=4.668,P=0.031).The overall survival was(9.13±3.14)months in the DEBTACE group,which was higher than that of(6.06±2.37)months in the C-TACE group,showing statistically significant difference(t=3.520,P=0.001).No serious adverse events occurred in either group postoperatively,and there were no differences in adverse reactions such as abdominal pain,fever,vomiting,renal dysfunction and inguinal hematoma between the two groups(χ^(2)=2.783,P=0.095).Conclusion The utilization of CalliSpheres drug-loaded microspheres in DEB-TACE represents a safe and effective treatment modality for unresectable intrahepatic cholangiocarcinoma,demonstrating superior efficacy when compared with C-TACE.