地夸磷索钠滴眼液对干眼症患者眼表和泪膜稳定性的影响

Effect of diquafosol sodium eye drops on ocular surface and tear film stability in patients with dry eye syndrome

目的 探讨地夸磷索钠滴眼液治疗干眼症的临床效果和对眼表泪膜稳定性的影响。方法 选取2023年3月至8月南方医科大学珠江医院收治的干眼症患者126例252眼,经随机数字表法分为观察组与对照组各63例(126眼),观察组给予3%地夸磷索钠滴眼液,对照组给予0.3%玻璃酸钠滴眼液。对比两组治疗有效率、角膜荧光染色(CFS)评分、眼部症状日常调查问卷(DEQS)评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)、睑板腺功能及结膜评分。结果 观察组治疗总有效率93.65%(118/126)高于对照组82.53%(104/126)(χ^(2)=7.416,P<0.05)。两组治疗后的CFS、DEQS、睑板腺功能、结膜评分均下降,观察组的CFS、DEQS、睑板腺功能、结膜评分[分别为(1.29±0.24)分、(3.12±0.44)分、(1.46±0.31)分、(1.12±0.28)分]低于对照组[分别为(1.52±0.36)分、(3.49±0.48)分、(1.57±0.36)分、(1.29±0.32)分](t=5.967、6.378、2.599、4.487,均P<0.05)。两组治疗后的BUT、SⅠT均升高,观察组的BUT、SⅠT[分别为(5.94±1.62) s、(11.10±3.62) mm·5 min^(-1)]高于对照组[分别为(5.13±1.47) s、(10.18±3.31) mm·5 min^(-1)](t=4.156、2.105,均P<0.05)。结论 地夸磷索钠滴眼治疗干眼症患者的疗效显著,可有效修复眼表损伤,提高患者泪膜稳定性,改善眼部症状和主观感受。

Objective To explore the clinical effect of 3%diquafosol sodium eye drops in the treatment of dry eye syndrome and its effect on the stability of the tear film on the ocular surface.Methods One hundred and twenty six patients(252 eyes)with dry eye syndrome admitted to Zhujiang Hospital of Southern Medical University from March to August 2023 were selected as the subjects,and grouped using random number table method.The 63 patients in the observation group(126 eyes)were given 3%diquafosol sodium eye drops and other 63 in the control group(126 eyes)were given 0.3%sodium hyaluronate eye drops.The treatment effective rate,corneal fluorescence staining(CFS)score,daily eye symptom questionnaire(DEQS)score,tear film breakup time(BUT),tear secretion test(SIT),meibomian gland function and conjunctival score were compared between the two groups.Results The clinical effective rate in the observation group was higher than that in the control(93.65%(118/126)vs 82.53%(104/126),χ^(2)=7.416,P<0.05).After treatment,a reduction in CFS,DEQS,meibomian gland function and conjunctival scores was found in both groups,and the scores of the observation group were lower than those of the control((1.29±0.24)scores vs(1.52±0.36)scores,(3.12±0.44)scores vs(3.49±0.48)scores,(1.46±0.31)scores vs(1.57±0.36)scores,(1.12±0.28)scores vs(1.29±0.32)scores,t=5.967,6.378,2.599,4.487,all P<0.05).BUT and SⅠT showed a decrease in all patients and they were higher in the observation group than in the control((5.94±1.62)s vs(5.13±1.47)s,(11.10±3.62)mm·5 min^(-1) vs(10.18±3.31)mm·5 min^(-1),t=4.156,2.105,both P<0.05).Conclusion The 3%diquafosol sodium eye drops have significant efficacy in the treatment of patients with dry eye syndrome.It can effectively repair ocular surface damage,promote the stability of the tear film and improve eye symptoms and subjective feelings.