中医药调节髓源性抑制细胞失调在恶性肿瘤中的研究进展

Research progress in the myeloid-derived suppressor cell dysregulation by traditional Chinese medicine in malignant tumors

髓源性抑制细胞(MDSCs)是一组具有免疫调节作用的髓系细胞。近年来,MDSCs在恶性肿瘤、自身免疫性疾病、感染性疾病、妊娠等领域受到广泛关注,尤其在恶性肿瘤中研究最为深入。文章概述了MDSCs及其在肿瘤微环境及恶性肿瘤治疗中的研究,聚焦于中医药调控MDSCs介导的免疫失衡问题,总结了中医药调节MDSCs失调在恶性肿瘤中的研究进展。文章通过对已有文献的分析,揭示中药单体、中药复方等通过抑制MDSCs的扩增、限制MDSCs激活、诱导MDSCs分化成熟、阻止MDSCs的募集等方式多途径、多靶点发挥作用,改善免疫抑制状态,从而达到抗肿瘤效果,文末提出中医药对MDSCs调控作用的研究方面尚存在的问题,以期为未来的恶性肿瘤临床治疗和药物开发提供参考。

Myeloid-derived suppressor cells(MDSCs)are a group of myeloid cells with immunomodulatory effect.In recent years,MDSCs has received extensive attention in the fields of malignant tumors,autoimmune diseases,infectious diseases,pregnancy and so on,especially in malignant tumors.This article summarizes MDSCs and its research in tumor microenvironment and therapy of malignant tumor,focuses on the regulation of MDSCs-mediated immune imbalance by traditional Chinese medicine,and summarizes the research progress of traditional Chinese medicine in regulating MDSCs imbalance in malignant tumor.Based on the analysis of existing literature,this paper revealed that traditional Chinese medicine monomers and compounds play a multi-channel and multi-target role to improve the immunosuppressive state by inhibiting the expansion of MDSCs,restricting the activation of MDSCs,inducing the differentiation and maturation of MDSCs,and preventing the recruitment of MDSCs,thus achieving anti-tumor effects.At the end of this paper,the existing problems in the study of the regulatory effect of traditional Chinese medicine on MDSCs were raised,in order to provide references for the future clinical treatment and drug development of malignant tumors.