无化疗放射治疗联合免疫检查点抑制剂治疗局部晚期非小细胞肺癌的研究进展

Research progress of chemotherapy-free radiation therapy combined with immune checkpoint inhibitors in the treatment of locally advanced non-small cell lung cancer

对不可切除的局部晚期非小细胞肺癌(LA-NSCLC)患者,同步放化疗后维持免疫检查点抑制剂治疗仍是标准的治疗方案。部分LA-NSCLC患者因各种原因不适合化疗,表现在治疗方案选择中对无化疗方案的需求。近期研究表明,放射治疗联合免疫检查点抑制剂的治疗策略有良好协同效应和潜在治疗价值。本文主要对无化疗放射治疗联合免疫检查点抑制剂治疗不可切除的LA-NSCLC进行系统总结,有助于更好地了解该治疗模式的机制、优势和局限性,为临床实践提供更有针对性的指导。

For patients with unresectable locally advanced non-small cell lung cancer(LA-NSCLC),maintenance of immune checkpoint inhibitors after concomitant radiochemotherapy remains the standard treatment regimen.Some LA-NSCLC patients are not suitable for chemotherapy due to various reasons,manifested in the need for no chemotherapy regimen in the selection of treatment plans.Recent studies have shown that radiation therapy combined with immune checkpoint inhibitors have good synergistic effects and potential therapeutic value as a treatment strategy.This article mainly provides systematic summary of chemotherapy-free radiation therapy combined with immune checkpoint inhibitors in the treatment of unresectable LA-NSCLC,which helps to better understand mechanism,advantages,and limitations of this treatment mode,and provides more targeted guidance for clinical practice.