基于VOSviewer和CiteSpace的三七总皂苷研究热点及发展趋势

Research hotspots and development trends of Panax notoginseng saponins based on VOSviewer and CiteSpace

目的分析三七总皂苷相关研究文献,掌握其发展历程、研究热点和发展趋势。方法检索中国知网、维普网、万方数据知识服务平台、中国生物医学文献和Web of Science核心合集数据库从建库至2024年4月收录的所有三七总皂苷相关中英文文献,通过VOSviewer 1.6.20、CiteSpace 6.3.R1、Pajek 645.18和NoteExpress 3.8对发文量、期刊来源、作者、研究机构、关键词进行分析。结果最终纳入2010篇中文文献,其中1703篇为期刊论文,307篇为学位论文,280篇英文文献,年度发文量总体呈波动上升趋势。中文文献主要发表于《中国中药杂志》《中国实验方剂学杂志》《中草药》等,英文文献主要发表于《Acta Pharmacologica Sinica》《Journal of Ethnopharmacology》等。中文文献作者共有4410名,英文文献有1476名,中英文发文量最多的分别是邓常清和ZHANG W。北京中医药大学中英文发文量均居于榜首,与多家机构合作,形成跨区域、有重要影响力的科研学术团体。中英文文献关键词分析结果显示,细胞凋亡、氧化应激、脑出血和再灌注损伤是三七总皂苷的热门方向。结论三七总皂苷的研究内容广泛,属于学科热门关注点,很多学者仍在深度挖掘其治疗疾病的价值和作用机制,分子机制上主要聚焦于细胞凋亡、氧化应激的作用途径,疾病治疗中脑出血、再灌注损伤是当前热点研究内容。

Objective To analyze relevant research literature of Panax notoginseng saponins,grasp its development history,research hotspots,and development trends.Methods All Chineses literatures and English literatures related to Panax notoginseng saponins in CNKI,VIP,Wanfang Data,Chinese Biomedical Literature,and Web of Science core collection database from inception to April 2024 were retrieved.Publication volume,journal sources,authors,research institutions,and keywords were analyzed by using VOSviewer 1.6.20,CiteSpace 6.3.R1,Pajek 645.18,and NoteExpress 3.8.Results Finally,2010 Chinese literatures were included,of which 1703 were journal papers,307 were degree papers,and 280 were English literatures.Overall annual publication volume showed a fluctuating upward trend.Chinese literature was mainly published in Chinese Journal of Traditional Chinese Medicine,Chinese Journal of Experimental Formula Studies,Chinese Herbal Medicine,etc.English literature was mainly published in Acta Pharmacologica Sinica,Journal of Ethnopharmacology,etc.There were a total of 4410 Chinese literature authors and 1476 English literature authors.Deng Changqing and ZHANG W had the highest number of publications in both Chinese and English,respectively.Beijing University of Chinese Medicine ranked first in both Chinese and English publications,collaborated with multiple institutions to form a cross regional and influential scientific research academic group.The analysis of key words in Chinese literature and English literature showed that apoptosis,oxidative stress,cerebral hemorrhage,and reperfusion injury were the popular directions for Panax notoginseng sap-onins.Conclusion The research content of Panax notoginseng saponins is extensive and belongs to a popular focus of attention in the discipline.Many scholars are still deeply exploring its value and mechanism of action in treating diseases.The molecular mechanism mainly focuses on the pathways of apoptosis and oxidative stress.The treatment of cerebral hemorrhage and reperfusion injury is currently a hot research topic.