脾胃培源方对脾胃虚弱型慢性萎缩性胃炎患者临床疗效及血清γ干扰素、肿瘤特异生长因子表达的影响

Effect of Piwei Peiyuan Decoction on clinical efficacy,serum interferon-γ,and tumor specific growth factor expression in chronic atrophic gastritis patients with spleen and stomach weakness type

目的探讨脾胃培源方对脾胃虚弱型慢性萎缩性胃炎(CAG)患者临床疗效及血清γ干扰素、肿瘤特异生长因子(TSGF)表达的影响。方法选取2022年9月至2023年9月于安徽中医药大学第二附属医院脾胃病科收治的64例脾胃虚弱型CAG患者,根据随机数字表法将其分为两组,每组32例。对照组口服胃复春片治疗,观察组服用脾胃培源方治疗,疗程12周。比较两组临床疗效、中医症状积分、胃镜和病理积分、胃功能指标、γ干扰素和TSGF水平。结果观察组临床疗效优于对照组(P<0.05)。治疗后,两组中医各症状积分均低于治疗前,且观察组胃脘胀满、胃脘疼痛、纳呆和食后脘闷积分均低于对照组(P<0.05)。治疗后,两组胃镜、病理积分均低于治疗前,且观察组胃镜积分及肠上皮化生、慢性炎症和活动性积分均低于对照组(P<0.05)。治疗后,两组胃泌素17(G-17)、胃蛋白酶原(PG)Ⅰ、PGⅡ和PGⅠ与PGⅡ比值(PGR)均高于治疗前,且观察组G-17、PGⅠ和PGR均高于对照组(P<0.05)。治疗后,两组γ干扰素和TSGF水平均低于治疗前,且观察组低于对照组(P<0.05)。结论脾胃培源方可有效缓解脾胃虚弱型CAG患者的临床症状,修复黏膜损伤,改善炎症环境,帮助患者恢复健康,值得推广应用。

Objective To explore the effcet of Piwei Peiyuan Decoction on clinical efficacy,serum interferon-γand tumor specific growth factor(TSGF)expression in chronic atrophic gastritis(CAG)patients with spleen and stomach weakness type.Methods A total of 64 CAG patients with spleen and stomach weakness type admitted to Department of Spleen and Stomach Diseases of the Second Affiliated Hospital of Anhui University of Chinese Medicine from September 2022 to September 2023 were selected,and they were divided into the two groups by using a random number table method,with 32 cases in each group.The control group was treated with oral Weifuchun Tablets,while the observation group was treated with Piwei Peiyuan Decoction for a course of 12 weeks.Clinical efficacy,traditional Chinese medicine symptom scores,gastroscopy and pathology scores,gastric function indicators,interferon-γ,and TSGF levels between the two groups were compared.Results Clinical efficacy of the observation group was better than that of the control group(P<0.05).After treatment,the scores of traditional Chinese medicine various symptoms in the two groups were lower than before treatment,and the scores of epigastric distension,epigastric pain,nausea and postprandial epigastric tightness in the observation group were lower than those in the control group(P<0.05).After treatment,the gastroscopy and pathology scores of the two groups were lower than before treatment,and the gastroscopy scores and intestinal metaplasia,chronic inflammation,and activity scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of gastrin 17(G-17),pepsinogen(PG)Ⅰ,PGⅡ,and PGⅠto PGⅡratio(PGR)in the two groups were higher than before treatment,and the levels of G-17,PGⅠ,and PGR in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of interferon-γand TSGF in the two groups were lower than before treatment,and those in the observation group were lower than those in the control group(P<0.05).Conclusion Piwei Peiyuan Decoction can effectively alleviate clinical symptoms of CAG patients with spleen and stomach weakness type,repair mucosal damage,improve inflammatory environment,and help patients recover their health.It is worth promoting and applying.