恩替卡韦与替诺福韦对乙肝患者的疗效

Effects of entecavir and tenofovir on patients with hepatitis B

目的分析恩替卡韦与替诺福韦对乙肝患者的影响,探讨乙肝更好的用药方法。方法选择滕州市中心人民医院2020年5月—2022年5月收治的乙肝患者84例,按照随机数字表法分为对照组和观察组,每组42例。对照组的患者给予恩替卡韦治疗,观察组患者给予替诺福韦治疗。比较两组表面抗原滴度、表面抗体滴度、肝功能指标、肝纤维化指标、治疗总有效率、不良反应发生率。结果治疗后,观察组表面抗原滴度低于对照组,表面抗体滴度高于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率为97.62%,高于对照组的80.95%,差异有统计学意义(χ^(2)=5.845,P<0.05)。两组治疗过程未见不良反应。观察组PTA、AST、TBIL、ALT指标优于对照组,差异均有统计学意义(P<0.05)。两组CIV、LV、PIIINP、HA指标均低于治疗前,且观察组各项指标低于对照组,差异均有统计学意义(P<0.05)。结论恩替卡韦与替诺福韦对乙肝患者的影响存在差异,替诺福韦的治疗效果更好,可有效改善肝功能,减轻肝纤维化,提高抗体滴度,降低抗原滴度。

Objective To analyze the influence of entecavir and tenofovir on hepatitis B patients,and to explore better medication methods.Methods A total of 84 patients with hepatitis B from May 2020 to May2022 in Tenzhou Central People's Hospital were selected and divided into control group and observation group with 42 cases in each group according to random number table methed.The patients in the control group were treated with entecavir,and the patients in the observation group were treated with tenofovir.The surface antigen titer,surface antibody titer,liver function index,liver fibrosis index,total effective rate of treatment and the incidence of adverse reaction were compared between the two groups.Results After treatment,the surface antigen titer of the observation group was lower than that of the control group,the surface antibody titer was higher than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment of the observation group was 97.62%,which was higher than 80.95%of the control group,and the difference was statistically significant(χ^(2)=5.845,P<0.05).No adverse reaction was found in the two groups during treatment.The PTA,AST,TBIL and ALT index of the observation group were better than those of the control group,and the differences were statistically significant(P<0.05).The CIV,LV,PIIINP and HA indicators in both groups were lower than those before treatment,and the observation group had lower indicators than the control group,and the differences were statistically significant(P<0.05).Conclusion The effects of entecavir and tenofovir on hepatitis B patients were different,among which tenofovir had a better therapeutic effect,which could better improve liver function,reduce liver fibrosis,increase antibody titer and reduce antigen titer.